日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analysis of a deeply-phenotyped familial hypercholesterolemia cohort from Mexico shows a role for both rare and common alleles across known dyslipidemia genes and reveals structural variation in a novel locus

对来自墨西哥的一个经过深入表型分析的家族性高胆固醇血症队列的研究表明,已知血脂异常基因中的罕见等位基因和常见等位基因均发挥作用,并揭示了一个新的基因位点的结构变异。

Katsanis, Nicholas; Mourtzi, Niki; Quinto-Cortés, Consuelo D; Martagon, Alexandro J; Ioannidis, Alexander G; De La Vega, Francisco M; Gulcher, Jeff; Lee, Ming Ta Michael; Faghihi, Mohammad A; Lopez-Pineda, Arturo; Moreno-Grau, Sonia; Montserrat, Daniel Mas; Barrabés, Míriam; Bonet, David; Fernandez, Pavel Salazar; Wall, Jeff; Moatamed, Babak; Mehta, Roopa; Galan-Ramirez, Gabriela A; Zubirán, Rafael; Elias-Lopez, Daniel; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A; Bustamante, Carlos D

Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures.

对原发性结直肠癌和转移进展进行蛋白质基因组学表征,可识别基于蛋白质组的亚型和特征

Tanaka Atsushi, Ogawa Makiko, Zhou Yihua, Namba Kei, Hendrickson Ronald C, Miele Matthew M, Li Zhuoning, Klimstra David S, Buckley Patrick G, Gulcher Jeffrey, Wang Julia Y, Roehrl Michael H A

Smooth Muscle Cell Reprogramming in Aortic Aneurysms

主动脉瘤平滑肌细胞重编程

Pei-Yu Chen ,Lingfeng Qin ,Guangxin Li ,Jose Malagon-Lopez ,Zheng Wang ,Sonia Bergaya ,Sharvari Gujja ,Alexander W Caulk ,Sae-Il Murtada ,Xinbo Zhang ,Zhen W Zhuang ,Deepak A Rao ,Guilin Wang ,Zuzana Tobiasova ,Bo Jiang ,Ruth R Montgomery ,Lele Sun ,Hongye Sun ,Edward A Fisher ,Jeffrey R Gulcher ,Carlos Fernandez-Hernando ,Jay D Humphrey ,George Tellides ,Thomas W Chittenden ,Michael Simons

Chronic mTOR activation induces a degradative smooth muscle cell phenotype

慢性 mTOR 激活诱导平滑肌细胞发生退行性表型

Guangxin Li ,Mo Wang ,Alexander W Caulk ,Nicholas A Cilfone ,Sharvari Gujja ,Lingfeng Qin ,Pei-Yu Chen ,Zehua Chen ,Sameh Yousef ,Yang Jiao ,Changshun He ,Bo Jiang ,Arina Korneva ,Matthew R Bersi ,Guilin Wang ,Xinran Liu ,Sameet Mehta ,Arnar Geirsson ,Jeffrey R Gulcher ,Thomas W Chittenden ,Michael Simons ,Jay D Humphrey ,George Tellides

In silico phenotype projection of endothelial ERK1/2 signaling

内皮细胞ERK1/2信号通路的计算机模拟表型预测

Simons, Michael; Gulcher, Jeffrey R; Chittenden, Thomas W

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis

内皮细胞TGF-β信号传导驱动血管炎症和动脉粥样硬化

Pei-Yu Chen ,Lingfeng Qin ,Guangxin Li ,Zheng Wang ,James E Dahlman ,Jose Malagon-Lopez ,Sharvari Gujja ,Nicholas A Cilfone ,Kevin J Kauffman ,Lele Sun ,Hongye Sun ,Xinbo Zhang ,Binod Aryal ,Alberto Canfran-Duque ,Rebecca Liu ,Pascal Kusters ,Alfica Sehgal ,Yang Jiao ,Daniel G Anderson ,Jeffrey Gulcher ,Carlos Fernandez-Hernando ,Esther Lutgens ,Martin A Schwartz ,Jordan S Pober ,Thomas W Chittenden ,George Tellides ,Michael Simons

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium

内皮细胞ERK1/2信号通路维持静息内皮的完整性。

Ricard, Nicolas; Scott, Rizaldy P; Booth, Carmen J; Velazquez, Heino; Cilfone, Nicholas A; Baylon, Javier L; Gulcher, Jeffrey R; Quaggin, Susan E; Chittenden, Thomas W; Simons, Michael

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

肥胖症中黑皮质素4受体通路功能障碍:旨在进行MC4R激动剂治疗的患者分层

Ayers, Kristin L; Glicksberg, Benjamin S; Garfield, Alastair S; Longerich, Simonne; White, Joseph A; Yang, Pengwei; Du, Lei; Chittenden, Thomas W; Gulcher, Jeffery R; Roy, Sophie; Fiedorek, Fred; Gottesdiener, Keith; Cohen, Sarah; North, Kari E; Schadt, Eric E; Li, Shuyu D; Chen, Rong; Van der Ploeg, Lex H T

A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer

一项基于全基因组测序的研究发现,8q24位点存在一种与前列腺癌相关的罕见变异。

Gudmundsson, Julius; Sulem, Patrick; Gudbjartsson, Daniel F; Masson, Gisli; Agnarsson, Bjarni A; Benediktsdottir, Kristrun R; Sigurdsson, Asgeir; Magnusson, Olafur Th; Gudjonsson, Sigurjon A; Magnusdottir, Droplaug N; Johannsdottir, Hrefna; Helgadottir, Hafdis Th; Stacey, Simon N; Jonasdottir, Adalbjorg; Olafsdottir, Stefania B; Thorleifsson, Gudmar; Jonasson, Jon G; Tryggvadottir, Laufey; Navarrete, Sebastian; Fuertes, Fernando; Helfand, Brian T; Hu, Qiaoyan; Csiki, Irma E; Mates, Ioan N; Jinga, Viorel; Aben, Katja K H; van Oort, Inge M; Vermeulen, Sita H; Donovan, Jenny L; Hamdy, Freddy C; Ng, Chi-Fai; Chiu, Peter K F; Lau, Kin-Mang; Ng, Maggie C Y; Gulcher, Jeffrey R; Kong, Augustine; Catalona, William J; Mayordomo, Jose I; Einarsson, Gudmundur V; Barkardottir, Rosa B; Jonsson, Eirikur; Mates, Dana; Neal, David E; Kiemeney, Lambertus A; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Stefansson, Kari

Discovery of common variants associated with low TSH levels and thyroid cancer risk

发现与低TSH水平和甲状腺癌风险相关的常见变异

Gudmundsson, Julius; Sulem, Patrick; Gudbjartsson, Daniel F; Jonasson, Jon G; Masson, Gisli; He, Huiling; Jonasdottir, Aslaug; Sigurdsson, Asgeir; Stacey, Simon N; Johannsdottir, Hrefna; Helgadottir, Hafdis Th; Li, Wei; Nagy, Rebecca; Ringel, Matthew D; Kloos, Richard T; de Visser, Marieke C H; Plantinga, Theo S; den Heijer, Martin; Aguillo, Esperanza; Panadero, Angeles; Prats, Enrique; Garcia-Castaño, Almudena; De Juan, Ana; Rivera, Fernando; Walters, G Bragi; Bjarnason, Hjordis; Tryggvadottir, Laufey; Eyjolfsson, Gudmundur I; Bjornsdottir, Unnur S; Holm, Hilma; Olafsson, Isleifur; Kristjansson, Kristleifur; Kristvinsson, Hoskuldur; Magnusson, Olafur T; Thorleifsson, Gudmar; Gulcher, Jeffrey R; Kong, Augustine; Kiemeney, Lambertus A L M; Jonsson, Thorvaldur; Hjartarson, Hannes; Mayordomo, Jose I; Netea-Maier, Romana T; de la Chapelle, Albert; Hrafnkelsson, Jon; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Stefansson, Kari