Targeting the JAK2-STAT3-UCHL3-ENO1 axis suppresses glycolysis and enhances the sensitivity to 5-FU chemotherapy in TP53-mutant colorectal cancer
靶向JAK2-STAT3-UCHL3-ENO1轴可抑制糖酵解并增强TP53突变型结直肠癌对5-氟尿嘧啶化疗的敏感性。
期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2025.03.041
Xin, Haisong; Zhao, Zitong; Guo, Shichao; Tian, Ruoxi; Ma, Liying; Yang, Yang; Zhao, Lianmei; Wang, Guanglin; Li, Baokun; Hu, Xuhua; Song, Yongmei; Wang, Guiying
肿瘤
肠癌
肿瘤免疫
JAK/STAT
JAK2
STAT3
P53