P23 acts as a negative regulator of ferroptosis in NSCLC by blocking GPX4 degradation via chaperone-mediated autophagy
P23通过分子伴侣介导的自噬阻断GPX4降解,从而在非小细胞肺癌中发挥铁死亡的负调控作用。
期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02439-y
Chen, Junlin; Peng, Yulin; Zhou, Meirong; Che, Yilin; Zhao, Shilei; He, Chengjian; Zhang, Wen; Tian, Xiangge; Zhang, Wenhao; Liu, Zhe; Zhou, Minghao; Liang, Guobiao; Huo, Xiaokui; Wang, Yan; Yu, Zhenlong; Ma, Xiaochi
肺癌
肿瘤
肿瘤免疫
信号转导
铁死亡
GPX4
细胞生物学
自噬