日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function

核苷酸结合的雷东多病毒Rep蛋白的结构、构象和功能

Montermoso, Saira; Gupta, Kushol; Pumroy, Ruth Anne; Moiseenkova-Bell, Vera; Bushman, Frederic D; Van Duyne, Gregory D

Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses

通过溶液生物物理分析解决靶向脂质纳米颗粒的异质性问题

Geisler, Hannah C; Safford, Hannah C; Thatte, Ajay S; Padilla, Marshall S; Battistini, Elisa; Yamagata, Hannah M; Ullman, Violet M; Chan, Alex; Nachod, Benjamin E; Agrawal, Anushka; Watkins, Maxwell B; Hopkins, Jesse B; Tsourkas, Andrew; Gupta, Kushol; Mitchell, Michael

Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors

变构抑制剂诱导的HIV-1整合酶聚合物体外耐药突变的结构影响

Montermoso, Saira; Eilers, Grant; Allen, Audrey; Sharp, Robert; Hwang, Young; Bushman, Frederic D; Gupta, Kushol; Duyne, Gregory Van

Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure

常规核小体和CENP-A核小体在溶液中的构象差异,在高压下的可逆形变会更加显著。

Gupta, Kushol; Sekulić, Nikolina; Allu, Praveen Kumar; Sapp, Nicklas; Huang, Qingqiu; Sarachan, Kathryn; Christensen, Mikkel; Lund, Reidar; Krueger, Susan; Curtis, Joseph E; Gillilan, Richard E; Van Duyne, Gregory D; Black, Ben E

Introduction to the SAMPREP special issue

SAMPREP 特刊简介

Gupta, Kushol

Elucidating lipid nanoparticle properties and structure through biophysical analyses

通过生物物理分析阐明脂质纳米颗粒的性质和结构

Padilla, Marshall S; Shepherd, Sarah J; Hanna, Andrew R; Kurnik, Martin; Zhang, Xujun; Chen, Michelle; Byrnes, James; Joseph, Ryann A; Yamagata, Hannah M; Ricciardi, Adele S; Mrksich, Kaitlin; Issadore, David; Gupta, Kushol; Mitchell, Michael J

Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude

通过多阶段混合来控制脂质纳米粒子的超分子结构,从而形成核壳结构,使性能提高几个数量级。

Nong, Jia; Gong, Xijing; Dang, Quang Minh; Tiwari, Sachchidanand; Patel, Manthan; Wu, Jichuan; Hanna, Andrew; Park, Wook-Jin; Atochina-Vasserman, Elena N; Huang, Hui-Ting; Marcos-Contreras, Oscar A; Morris-Blanco, Kahlilia C; Miner, Jonathan J; Weissman, Drew; Muzykantov, Vladimir R; Gupta, Kushol; Issadore, David; Myerson, Jacob W; Wang, Zhicheng; Brenner, Jacob S

The LexA-RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation

LexA-RecA*结构揭示了一种用于SOS激活的隐秘锁钥机制。

Cory, Michael B; Li, Allen; Hurley, Christina M; Carman, Peter J; Pumroy, Ruth A; Hostetler, Zachary M; Perez, Ryann M; Venkatesh, Yarra; Li, Xinning; Gupta, Kushol; Petersson, E James; Kohli, Rahul M

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

高级SMN寡聚体的组装对于后生动物的生存至关重要,并且需要YG拉链二聚体中存在的暴露结构基序。

Gupta, Kushol; Wen, Ying; Ninan, Nisha S; Raimer, Amanda C; Sharp, Robert; Spring, Ashlyn M; Sarachan, Kathryn L; Johnson, Meghan C; Van Duyne, Gregory D; Matera, A Gregory

Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions.

变构 HIV 整合酶抑制剂通过同源羧基末端结构域相互作用促进无活性支链聚合物的形成

Gupta Kushol, Allen Audrey, Giraldo Carolina, Eilers Grant, Sharp Robert, Hwang Young, Murali Hemma, Cruz Katrina, Janmey Paul, Bushman Frederic, Van Duyne Gregory D