Gupta Mahesh P相关文献与解析，生知库 | 链接生命科学的每一步

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

核内sirtuin SIRT6保护心脏免受与衰老相关的心肌细胞衰老和心脏肥大的影响。

期刊:Aging-Us

影响因子:3.9

doi:10.18632/aging.203027

Pillai, Vinodkumar B; Samant, Sadhana; Hund, Samantha; Gupta, Madhu; Gupta, Mahesh P

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

核和线粒体的 Sirtuins（Sirt6 和 Sirt3）相互调节彼此的活动，保护心脏免于患上肥胖介导的糖尿病性心肌病

期刊:FASEB Journal

影响因子:4.4

doi:10.1096/fj.201900767R

Abhinav Kanwal, Vinodkumar B Pillai, Sadhana Samant, Madhu Gupta, Mahesh P Gupta

Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism

心肌细胞特异性microRNA-378的缺乏会导致心肌纤维化的发展，这一过程涉及转化生长因子β（TGFβ1）依赖的旁分泌机制。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.A114.580977

Nagalingam, Raghu S; Sundaresan, Nagalingam R; Noor, Mariam; Gupta, Mahesh P; Solaro, R John; Gupta, Madhu

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage

SIRT3通过阻止线粒体DNA损伤来抑制肌成纤维细胞分化和肺纤维化。

期刊:American Journal of Physiology-Lung Cellular and Molecular Physiology

影响因子:3.5

doi:10.1152/ajplung.00188.2016

Bindu, Samik; Pillai, Vinodkumar B; Kanwal, Abhinav; Samant, Sadhana; Mutlu, Gökhan M; Verdin, Eric; Dulin, Nickolai; Gupta, Mahesh P

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

厚朴酚是Sirtuin-3 (SIRT3) 的激活剂，能够保护线粒体并防止小鼠心脏受到阿霉素诱导的心肌病损害。

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.16133

Pillai, Vinodkumar B; Kanwal, Abhinav; Fang, Yong Hu; Sharp, Willard W; Samant, Sadhana; Arbiser, Jack; Gupta, Mahesh P

Understanding the Interactions between the Proteins Implicated in Legius Syndrome and Neurofibromatosis Type 1(♦): Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1

了解与Legius综合征和1型神经纤维瘤病相关的蛋白质之间的相互作用(♦)：Ras-ERK通路负调控因子SPRED1蛋白的结构域与神经纤维蛋白的GTP酶激活蛋白相关结构域之间的相互作用与Legius综合征和1型神经纤维瘤病有关

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.A112.442384

Nagalingam, Raghu S; Sundaresan, Nagalingam R; Gupta, Mahesh P; Geenen, David L; Solaro, R John; Gupta, Madhu

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

SIRT3在系统性硬化症的皮肤和肺部中表达减弱，而其药理学激活可减轻器官纤维化。

期刊:Oncotarget

影响因子:

doi:10.18632/oncotarget.12504

Akamata, Kaname; Wei, Jun; Bhattacharyya, Mitra; Cheresh, Paul; Bonner, Michael Y; Arbiser, Jack L; Raparia, Kirtee; Gupta, Mahesh P; Kamp, David W; Varga, John

Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging

Sirtuins 对 Akt 信号通路的调控：其在心脏肥大和衰老中的作用

期刊:Circulation Research

影响因子:16.2

doi:10.1161/CIRCRESAHA.113.300536

Pillai, Vinodkumar B; Sundaresan, Nagalingam R; Gupta, Mahesh P

Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor Î² (TGFÎ²1)-dependent paracrine mechanism.

心肌细胞特异性microRNA-378的缺乏会导致心脏纤维化的发展，其中涉及转化生长因子β（TGFβ1）依赖的旁分泌机制

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.M114.580977

Nagalingam Raghu S, Sundaresan Nagalingam R, Noor Mariam, Gupta Mahesh P, Solaro R John, Gupta Madhu

The multifaceted role of sirtuins in inflammatory bowel diseases

sirtuins在炎症性肠病中的多重作用

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

核内sirtuin SIRT6保护心脏免受与衰老相关的心肌细胞衰老和心脏肥大的影响。

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

核和线粒体的 Sirtuins（Sirt6 和 Sirt3）相互调节彼此的活动，保护心脏免于患上肥胖介导的糖尿病性心肌病

Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism

心肌细胞特异性microRNA-378的缺乏会导致心肌纤维化的发展，这一过程涉及转化生长因子β（TGFβ1）依赖的旁分泌机制。

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage

SIRT3通过阻止线粒体DNA损伤来抑制肌成纤维细胞分化和肺纤维化。

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

厚朴酚是Sirtuin-3 (SIRT3) 的激活剂，能够保护线粒体并防止小鼠心脏受到阿霉素诱导的心肌病损害。

了解与Legius综合征和1型神经纤维瘤病相关的蛋白质之间的相互作用(♦)：Ras-ERK通路负调控因子SPRED1蛋白的结构域与神经纤维蛋白的GTP酶激活蛋白相关结构域之间的相互作用与Legius综合征和1型神经纤维瘤病有关

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

SIRT3在系统性硬化症的皮肤和肺部中表达减弱，而其药理学激活可减轻器官纤维化。

Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging

Sirtuins 对 Akt 信号通路的调控：其在心脏肥大和衰老中的作用

Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor Î² (TGFÎ²1)-dependent paracrine mechanism.

心肌细胞特异性microRNA-378的缺乏会导致心脏纤维化的发展，其中涉及转化生长因子β（TGFβ1）依赖的旁分泌机制