日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein-VDAC complexation as a potential therapeutic target for Parkinson's disease treatment

通过抑制 α-突触核蛋白-VDAC 复合来限制 α-突触核蛋白转运到线粒体,作为帕金森病治疗的潜在治疗靶点

Megha Rajendran, María Queralt-Martín, Philip A Gurnev #, William M Rosencrans, Amandine Rovini, Daniel Jacobs, Kaitlin Abrantes, David P Hoogerheide, Sergey M Bezrukov, Tatiana K Rostovtseva

Tunable Electromechanical Nanopore Trap Reveals Populations of Peripheral Membrane Protein Binding Conformations

可调谐电机械纳米孔陷阱揭示外周膜蛋白结合构象的分布

Hoogerheide, David P; Rostovtseva, Tatiana K; Jacobs, Daniel; Gurnev, Philip A; Bezrukov, Sergey M

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

奥利索西通过靶向 α-突触核蛋白与线粒体 VDAC 相互作用介导神经保护的分子机制

Amandine Rovini, Philip A Gurnev, Alexandra Beilina, María Queralt-Martín, William Rosencrans, Mark R Cookson, Sergey M Bezrukov, Tatiana K Rostovtseva

Sequence diversity of tubulin isotypes in regulation of the mitochondrial voltage-dependent anion channel

微管蛋白同种型序列多样性在调节线粒体电压依赖性阴离子通道中的作用

Tatiana K Rostovtseva, Philip A Gurnev, David P Hoogerheide, Amandine Rovini, Minhajuddin Sirajuddin, Sergey M Bezrukov

Cation-Selective Channel Regulated by Anions According to Their Hofmeister Ranking

根据霍夫迈斯特排序,阴离子调控阳离子选择性通道

Gurnev, Philip A; Roark, Torri C; Petrache, Horia I; Sodt, Alexander J; Bezrukov, Sergey M

Poly(ethylene glycol)s in Semidilute Regime: Radius of Gyration in the Bulk and Partitioning into a Nanopore

半稀溶液状态下聚乙二醇:本体回转半径及其在纳米孔中的分配

Gurnev, Philip A; Stanley, Christopher B; Aksoyoglu, M Alphan; Hong, Kunlun; Parsegian, V Adrian; Bezrukov, Sergey M

Size-dependent forced PEG partitioning into channels: VDAC, OmpC, and α-hemolysin

尺寸依赖性强制PEG分配到通道中:VDAC、OmpC和α-溶血素

Aksoyoglu, M Alphan; Podgornik, Rudolf; Bezrukov, Sergey M; Gurnev, Philip A; Muthukumar, Murugappan; Parsegian, V Adrian

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

α-突触核蛋白与电压依赖性阴离子通道表现出高亲和力相互作用,提示其可能参与帕金森病中线粒体的调控和毒性机制

Rostovtseva, Tatiana K; Gurnev, Philip A; Protchenko, Olga; Hoogerheide, David P; Yap, Thai Leong; Philpott, Caroline C; Lee, Jennifer C; Bezrukov, Sergey M

Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40

线粒体外膜蛋白转位酶孔Tom40的不同通道构象和底物结合亲和力的证据

Kuszak, Adam J; Jacobs, Daniel; Gurnev, Philip A; Shiota, Takuya; Louis, John M; Lithgow, Trevor; Bezrukov, Sergey M; Rostovtseva, Tatiana K; Buchanan, Susan K

Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC)

微管蛋白尾部序列和翻译后修饰调节线粒体电压依赖性阴离子通道(VDAC)的关闭

Sheldon, Kely L; Gurnev, Philip A; Bezrukov, Sergey M; Sackett, Dan L