日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours

强有力的人类遗传学证据支持FGF21对减少饮酒行为的因果作用

Cronjé, Héléne T; Hu, Sile; Gurrell, Rachel; Vujkovic, Marijana; Larsson, Susanna C; Mason, Richard; Butt, Richard; Gill, Dipender

Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine.

MEDI0618 是一种 pH 依赖性单克隆抗体,靶向 PAR2,在偏头痛的临床前模型中疗效

Kopruszinski Caroline M, Linley John E, Thornton Peter, Walker Alison S, Newton Philip, Podichetty Sadhana, Ruparel Radhey Hemendra, Moreira de Souza Luiz Henrique, Navratilova Edita, Meno-Tetang Guy, Gurrell Ian, Dodick David W, Dobson Claire, Chessell Tharani, Porreca Frank, Chessell Iain

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours

强有力的人类遗传学证据支持FGF21对减少饮酒行为的因果作用

Cronjé, Héléne T; Hu, Sile; Gurrell, Rachel; Vujkovic, Marijana; Larsson, Susanna C; Mason, Richard; Butt, Richard; Gill, Dipender

Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

直接激活 KCC2 可抑制小鼠苯二氮卓类药物难治性癫痫持续状态并限制随后的神经元损伤

Rebecca Jarvis, Shu Fun Josephine Ng, Anna J Nathanson, Ross A Cardarelli, Krithika Abiraman, Fergus Wade, Aidan Evans-Strong, Marina P Fernandez-Campa, Tarek Z Deeb, Joshua L Smalley, Tanguy Jamier, Ian K Gurrell, Lisa McWilliams, Aarti Kawatkar, Leslie C Conway, Qi Wang, Roland W Burli, Nicholas J

Considerations for determining the efficacy of new antiseizure medications in children age 1 month to younger than 2 years

评估新型抗癫痫药物对1个月至2岁以下儿童疗效的考量因素

French, Jacqueline A; Cleary, Elena; Dlugos, Dennis; Farfel, Gail; Farrell, Kathleen; Gidal, Barry; Grzeskowiak, Caitlin L; Gurrell, Rachel; Harden, Cynthia; Stalvey, Tracy J; Tsai, Julia; Wirrell, Elaine C; Blum, David; Fountain, Nathan

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy

抗体-寡核苷酸偶联物在脊髓性肌萎缩动物模型中实现了中枢神经系统递送

Suzan M Hammond, Frank Abendroth, Larissa Goli, Jessica Stoodley, Matthew Burrell, George Thom, Ian Gurrell, Nina Ahlskog, Michael J Gait, Matthew Ja Wood, Carl I Webster

Pronounced antiseizure activity of the subtype-selective GABA(A) positive allosteric modulator darigabat in a mouse model of drug-resistant focal epilepsy

在药物难治性局灶性癫痫小鼠模型中,亚型选择性GABA(A)正向变构调节剂darigabat表现出显著的抗癫痫活性

Gurrell, Rachel; Iredale, Philip; Evrard, Alexis; Duveau, Venceslas; Ruggiero, Céline; Roucard, Corinne

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

通过药理学激活 tau 蛋白病神经元的自噬来延长 tau 蛋白清除时间并挽救应激脆弱性

M Catarina Silva, Ghata A Nandi, Sharon Tentarelli, Ian K Gurrell, Tanguy Jamier, Diane Lucente, Bradford C Dickerson, Dean G Brown, Nicholas J Brandon, Stephen J Haggarty

Pronounced antiepileptic activity of the subtype-selective GABA(A) -positive allosteric modulator PF-06372865 in the GAERS absence epilepsy model

在GAERS失神癫痫模型中,亚型选择性GABA(A)正向变构调节剂PF-06372865表现出显著的抗癫痫活性

Duveau, Venceslas; Buhl, Derek L; Evrard, Alexis; Ruggiero, Céline; Mandé-Niedergang, Betty; Roucard, Corinne; Gurrell, Rachel

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

一种源自黑素转铁蛋白的肽可跨 BBB 递送基于蛋白质的白细胞介素 1 受体拮抗剂,并在临床前模型中缓解神经性疼痛

George Thom, Mei-Mei Tian, Jon P Hatcher, Natalia Rodrigo, Matthew Burrell, Ian Gurrell, Timothy Z Vitalis, Thomas Abraham, Wilfred A Jefferies, Carl I Webster, Reinhard Gabathuler