日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

KRASG12R突变型胰腺癌具有ERK/MAPK转录活性受限和独特的肿瘤微环境。

Burge, Rachel A; Le Roux, Ozgun; Popow, Olesja; Spadafora, Victoria K; Rajesh, Christabelle; Adair, Sara J; Bialousow, Lucas; Murphy, Cailey; Saberi, Samaneh; Vaena, Silvia G; Taquey, Margaret C; Allen, Sarah; Han, Lu; Helke, Kristi L; Sharma, Sudarshana; Ostrowski, Michael C; Guttridge, Denis C; Dincman, Toros A; Bauer, Todd W; Kashatus, David F; McFall, Thomas; Haigis, Kevin M; Hollingsworth, Michael A; Counter, Christopher M; Der, Channing J; Hobbs, G Aaron

High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia

高脂饮食和肥胖均会加剧实验性癌症恶病质中的肿瘤细胞增殖和肌肉萎缩。

Counts, Brittany R; Bonetto, Andrea; Chan, Ho Lam; Au, Ernie D; Jiang, Yanlin; Couch, Marion E; Guttridge, Denis C; Ostrowski, Michael C; Koniaris, Leonidas G; Zimmers, Teresa A

New models of implantation: towards a whole better than the sum of parts

新型植入模式:整体优于部分之和

Rawlings, T M; Guttridge, S A; Lucas, E S

Long-lived entanglement of molecules in magic-wavelength optical tweezers

魔波长光镊中分子的长寿命纠缠

Ruttley, Daniel K; Hepworth, Tom R; Guttridge, Alexander; Cornish, Simon L

Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia

一项随机II期研究比较了紫杉醇纳米粒联合吉西他滨(加或不加托珠单抗)作为晚期胰腺癌一线治疗方案的疗效:生存率和恶病质

Chen, Inna M; Johansen, Julia S; Theile, Susann; Silverman, Libbie M; Pelz, Katherine R; Madsen, Kasper; Dajani, Olav; Lim, Kevin Z M; Lorentzen, Torben; Gaafer, Omnia; Koniaris, Leonidas G; Ferreira, Anna C; Neelon, Brian; Guttridge, Denis C; Ostrowski, Michael C; Zimmers, Teresa A; Nielsen, Dorte

Long-lived multilevel coherences and spin-1 dynamics encoded in the rotational states of ultracold molecules

超冷分子旋转态中编码的长寿命多级相干性和自旋-1动力学

Hepworth, Tom R; Ruttley, Daniel K; von Gierke, Fritz; Gregory, Philip D; Guttridge, Alexander; Cornish, Simon L

Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer

利用工程化趋化因子融合蛋白调节CXCR2信号通路以破坏胰腺癌中的髓系细胞浸润

Benjamin N Christopher ,Lena Golick ,Ashton Basar ,Leticia Reyes ,Reeder M Robinson ,Aaron O Angerstein ,Carsten Krieg ,G Aaron Hobbs ,Denis C Guttridge ,John P O'Bryan ,Nathan G Dolloff

MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD

MyoD在横纹肌肉瘤中发挥着至关重要的作用,它通过促进分化和CYLD来提高细胞存活率。

Alexander R Oles ,Peter Y Yu ,Abasi-Ama Udeme ,Sudarshana Sharma ,Priya Londhe ,Benjamin R Pryce ,Erin E Talbert ,Eric M Hill ,Carlos J Miranda ,Brian K Kaspar ,Michael A Arnold ,Jack Hyland ,Cheryl A London ,Peter J Houghton ,David J Wang ,Ryan D Roberts ,Denis C Guttridge

Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing

阻断去分化脂肪肉瘤(DDLPS)中的白细胞介素-6(IL-6)信号传导可通过选择性剪接降低小鼠双微体2(MDM2)的致癌性

Zewdu, Abeba; Braggio, Danielle; Lopez, Gonzalo; Batte, Kara; Khurshid, Safiya; Costas C de Faria, Fernanda; Bid, Hemant K; Koller, David; Casadei, Lucia; Ladner, Katherine J; Wang, David; Grignol, Valerie; Iwenofu, O Hans; Chandler, Dawn; Guttridge, Denis C; Pollock, Raphael E

Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in Skeletal Muscle Myocytes

胰腺癌诱导骨骼肌肌细胞中肌球蛋白亚型发生群体特异性转换,并离散激活恶病质基因

Counts, Brittany R; Jean, Sephora; Gaafer, Omnia; Ota, Sara K; Inabathini, Iishaan; Guo, Tingbo; Guttridge, Denis C; Ostrowski, Michael C; Koniaris, Leonidas G; Cao, Sha; Roh, Hyun C; Zimmers, Teresa A