PD-1 up-regulation on CD4(+) T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production
CD4(+) T细胞上PD-1的上调通过STAT3介导的IL-17A和TGF-β1的产生促进肺纤维化。
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.aar8356
Celada, Lindsay J; Kropski, Jonathan A; Herazo-Maya, Jose D; Luo, Weifeng; Creecy, Amy; Abad, Andrew T; Chioma, Ozioma S; Lee, Grace; Hassell, Natalie E; Shaginurova, Guzel I; Wang, Yufen; Johnson, Joyce E; Kerrigan, Amy; Mason, Wendi R; Baughman, Robert P; Ayers, Gregory D; Bernard, Gordon R; Culver, Daniel A; Montgomery, Courtney G; Maher, Toby M; Molyneaux, Philip L; Noth, Imre; Mutsaers, Steven E; Prele, Cecilia M; Peebles, R S Jr; Newcomb, Dawn C; Kaminski, Naftali; Blackwell, Timothy S; Van Kaer, Luc; Drake, Wonder P
T细胞
IL-17
JAK/STAT
IL-17A
PD-1
TGF-β
STAT3
T细胞
TGF-β1
细胞生物学
CD4
免疫/内分泌