Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA.
Sirtuin 2 抑制剂 AGK2 通过募集抑制性组蛋白赖氨酸甲基转移酶和减少 cccDNA，诱导乙型肝炎病毒共价闭合环状 DNA 的表观遗传抑制，从而发挥抗病毒作用
期刊:Frontiers in Cellular and Infection Microbiology
影响因子:4.8
doi:10.3389/fcimb.2025.1537929
Kim Jumi, Ha Jiseon, Song Chanho, Sajjad Muhammad Azhar, Kalsoom Fadia, Kwon Hyeonjoong, Park Jaewoo, Park Sun, Kim Kyongmin
