日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed

揭示α-突触核蛋白在脂质膜上聚集的分子机制

Dear, Alexander J; Teng, Xiangyu; Ball, Sarah R; Lewin, Joshua; Horne, Robert I; Clow, Daniel; Stevenson, Alisdair; Harper, Natasha; Yahya, Kim; Yang, Xiaoting; Brewerton, Suzanne C; Thomson, John; Michaels, Thomas C T; Linse, Sara; Knowles, Tuomas P J; Habchi, Johnny; Meisl, Georg

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

基于结构的α-突触核蛋白聚集体自催化增殖小分子抑制剂的发现

Chia, Sean; Faidon Brotzakis, Z; Horne, Robert I; Possenti, Andrea; Mannini, Benedetta; Cataldi, Rodrigo; Nowinska, Magdalena; Staats, Roxine; Linse, Sara; Knowles, Tuomas P J; Habchi, Johnny; Vendruscolo, Michele

Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response

出版商更正:两种人类代谢物通过胞质未折叠蛋白反应挽救秀丽隐杆线虫阿尔茨海默病模型

Joshi, Priyanka; Perni, Michele; Limbocker, Ryan; Mannini, Benedetta; Casford, Sam; Chia, Sean; Habchi, Johnny; Labbadia, Johnathan; Dobson, Christopher M; Vendruscolo, Michele

Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

出版商更正:多巴胺代谢物可稳定神经毒性β-淀粉样蛋白寡聚体

Cataldi, Rodrigo; Chia, Sean; Pisani, Katarina; Ruggeri, Francesco S; Xu, Catherine K; Šneideris, Tomas; Perni, Michele; Sarwat, Sunehera; Joshi, Priyanka; Kumita, Janet R; Linse, Sara; Habchi, Johnny; Knowles, Tuomas P J; Mannini, Benedetta; Dobson, Christopher M; Vendruscolo, Michele

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

鲨胺及其衍生物调节β-淀粉样蛋白和α-突触核蛋白的聚集,并抑制其寡聚体的毒性

Limbocker, Ryan; Staats, Roxine; Chia, Sean; Ruggeri, Francesco S; Mannini, Benedetta; Xu, Catherine K; Perni, Michele; Cascella, Roberta; Bigi, Alessandra; Sasser, Liam R; Block, Natalie R; Wright, Aidan K; Kreiser, Ryan P; Custy, Edward T; Meisl, Georg; Errico, Silvia; Habchi, Johnny; Flagmeier, Patrick; Kartanas, Tadas; Hollows, Jared E; Nguyen, Lam T; LeForte, Kathleen; Barbut, Denise; Kumita, Janet R; Cecchi, Cristina; Zasloff, Michael; Knowles, Tuomas P J; Dobson, Christopher M; Chiti, Fabrizio; Vendruscolo, Michele

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

以抑制α-突触核蛋白聚集过程中寡聚体形成为筛选参数的小分子

Staats, Roxine; Michaels, Thomas C T; Flagmeier, Patrick; Chia, Sean; Horne, Robert I; Habchi, Johnny; Linse, Sara; Knowles, Tuomas P J; Dobson, Christopher M; Vendruscolo, Michele

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

Trodusquemine通过一种通用机制将错误折叠的蛋白质寡聚体从细胞膜上置换下来,并消除其细胞毒性。

Limbocker, Ryan; Mannini, Benedetta; Ruggeri, Francesco S; Cascella, Roberta; Xu, Catherine K; Perni, Michele; Chia, Sean; Chen, Serene W; Habchi, Johnny; Bigi, Alessandra; Kreiser, Ryan P; Wright, Aidan K; Albright, J Alex; Kartanas, Tadas; Kumita, Janet R; Cremades, Nunilo; Zasloff, Michael; Cecchi, Cristina; Knowles, Tuomas P J; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

利用细菌生产和直接功能筛选扩增的分子库,以发现蛋白质聚集抑制剂

Delivoria, Dafni C; Chia, Sean; Habchi, Johnny; Perni, Michele; Matis, Ilias; Papaevgeniou, Nikoletta; Reczko, Martin; Chondrogianni, Niki; Dobson, Christopher M; Vendruscolo, Michele; Skretas, Georgios

SAR by kinetics for drug discovery in protein misfolding diseases

利用动力学进行结构-活性关系研究以发现蛋白质错误折叠疾病的药物

Chia, Sean; Habchi, Johnny; Michaels, Thomas C T; Cohen, Samuel I A; Linse, Sara; Dobson, Christopher M; Knowles, Tuomas P J; Vendruscolo, Michele

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

单体和纤维状α-突触核蛋白对促进Aβ42聚集体增殖的催化循环产生相反的作用。

Chia, Sean; Flagmeier, Patrick; Habchi, Johnny; Lattanzi, Veronica; Linse, Sara; Dobson, Christopher M; Knowles, Tuomas P J; Vendruscolo, Michele