Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells
靶向 CRISPR 筛选确定 PRMT5 是胰腺癌细胞中与吉西他滨合成致死组合靶点
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2009899117
Xiaolong Wei, Jiekun Yang, Sara J Adair, Harun Ozturk, Cem Kuscu, Kyung Yong Lee, William J Kane, Patrick E O'Hara, Denis Liu, Yusuf Mert Demirlenk, Alaa Hamdi Habieb, Ebru Yilmaz, Anindya Dutta, Todd W Bauer, Mazhar Adli