日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Separating selection from mutation in antibody language models

在抗体语言模型中区分选择和突变

Matsen, Frederick A 4th; Dumm, Will; Sung, Kevin; Johnson, Mackenzie M; Rich, David H; Starr, Tyler N; Song, Yun S; Fukuyama, Julia; Haddox, Hugh K

Clonal interference and changing selective pressures shape the escape of SARS-CoV-2 from hundreds of antibodies

克隆干扰和不断变化的选择压力影响着SARS-CoV-2病毒逃避数百种抗体的能力

Haddox, Hugh K; Abdel Aziz, Omar; Galloway, Jared G; Kent, Javen; Cooper, Cameron R; Jennings-Shaffer, Chris; Dumm, Will; Temple, Seth D; Bloom, Jesse D; Matsen, Frederick A 4th

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure

SARS-CoV-2的突变率在不同位点之间差异很大,并受序列环境、基因组区域和RNA结构的影响。

Haddox, Hugh K; Angehrn, Georg; Sesta, Luca; Jennings-Shaffer, Chris; Temple, Seth D; Galloway, Jared G; Hinrichs, Angie S; DeWitt, William S; Bloom, Jesse D; Iv, Frederick A Matsen; Neher, Richard A

Computational design of sequence-specific DNA-binding proteins

序列特异性DNA结合蛋白的计算设计

Glasscock, Cameron J; Pecoraro, Robert J; McHugh, Ryan; Doyle, Lindsey A; Chen, Wei; Boivin, Olivier; Lonnquist, Beau; Na, Emily; Politanska, Yuliya; Haddox, Hugh K; Cox, David; Norn, Christoffer; Coventry, Brian; Goreshnik, Inna; Vafeados, Dionne; Lee, Gyu Rie; Gordân, Raluca; Stoddard, Barry L; DiMaio, Frank; Baker, David

Landscape of chimeric RNAs in COVID-19 patient blood.

新冠肺炎患者血液中嵌合RNA的分布情况

Haddox Samuel, Wu Ping, Singh Sandeep, Qin Fujun, Engel Jack, Kian Andrea, Ahmad Syed, Li Hui, Wu Peng

Thrifty wide-context models of B cell receptor somatic hypermutation

B细胞受体体细胞高频突变的节俭型广义模型

Sung, Kevin; Johnson, Mackenzie M; Dumm, Will; Simon, Noah; Haddox, Hugh; Fukuyama, Julia; Matsen, Frederick A

Genomic Characterization of Chondrosarcoma Reveals Potential Therapeutic Targets

软骨肉瘤的基因组特征分析揭示了潜在的治疗靶点

Wagner, Michael J; Pimenta, Erica M; Sweeney, Nathan W; Loggers, Elizabeth T; Roberts, Jesse L; Brinkman, Elyse; Chen, Eleanor Y; Ricciotti, Robert; Haddox, Candace L; Berg, Rachel; Yilma, Binyam; Stoppler, Melissa C; Chen, James L; Cranmer, Lee D

A Sitewise Model of Natural Selection on Individual Antibodies via a Transformer-Encoder

基于Transformer编码器的单抗体自然选择位点模型

Matsen, Frederick A 4th; Sung, Kevin; Johnson, Mackenzie M; Dumm, Will; Rich, David; Starr, Tyler N; Song, Yun S; Bradley, Philip; Fukuyama, Julia; Haddox, Hugh K

Nucleotide context models outperform protein language models for predicting antibody affinity maturation

核苷酸上下文模型在预测抗体亲和力成熟方面优于蛋白质语言模型

Johnson, Mackenzie M; Sung, Kevin; Haddox, Hugh K; Vora, Ashni A; Araki, Tatsuya; Victora, Gabriel D; Song, Yun S; Fukuyama, Julia; Matsen Iv, Frederick A

Separating selection from mutation in antibody language models

在抗体语言模型中区分选择和突变

Matsen, Frederick A 4th; Dumm, Will; Sung, Kevin; Johnson, Mackenzie M; Rich, David; Starr, Tyler; Song, Yun S; Fukuyama, Julia; Haddox, Hugh K