日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A review of evidence supporting amyloid beta reduction as a surrogate endpoint in Alzheimer's disease

对支持以β-淀粉样蛋白减少作为阿尔茨海默病替代终点的证据进行综述

Chen, Tianle; Hutchison, R Matthew; Rubel, Carrie; Murphy, Jennifer; Xie, Jing; O'Gorman, John; Dent, Gersham; Molenberghs, Geert; Sormani, Maria Pia; Hendrix, Suzanne; Hansson, Oskar; Aisen, Paul; Haeberlein, Samantha Budd; Tian, Ying

Curation of the Fasciola hepatica kinome as a resource for drug target discovery

将肝片吸虫激酶组数据整理为药物靶点发现的资源

Ajmera, Sagar; Puckelwaldt, Oliver; Stroehlein, Andreas J; Haeberlein, Simone

The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.

通过对卵巢细胞进行单细胞转录组学分析发现的视黄酸家族样核受体 SmRAR 控制曼氏血吸虫卵母细胞的分化

Moescheid Max F, Lu Zhigang, Soria Carmen Diaz, Quack Thomas, Puckelwaldt Oliver, Holroyd Nancy, Holzaepfel Pauline, Haeberlein Simone, Rinaldi Gabriel, Berriman Matthew, Grevelding Christoph G

Evaluation of cognitive, functional, and behavioral effects observed in EMERGE, a phase 3 trial of aducanumab in people with early Alzheimer's disease

对 EMERGE 研究中观察到的认知、功能和行为效应进行评估,EMERGE 是一项针对早期阿尔茨海默病患者的 aducanumab 三期临床试验。

Cummings, Jeffrey; Cohen, Sharon; Murphy, Jennifer; Brothers, Holly M; Nejati, Mina; Forrestal, Fiona; de Moor, Carl; O'Gorman, John; Harrison, John; Jaeger, Judith; Mummery, Catherine Jane; Porsteinsson, Anton P; Potashman, Michele; Tian, Ying; Yang, Lili; He, Ping; Haeberlein, Samantha Budd

Pharmacological Inhibition of c-Jun N-Terminal Kinase Activity Exacerbates Liver Damage in Schistosoma mansoni Infected Mice.

药理学抑制 c-Jun N 端激酶活性会加剧曼氏血吸虫感染小鼠的肝损伤

Stettler Frederik, Knedla Lukas, Hagen Maximilian, von Bülow Verena, Müller Heike, Tschuschner Annette, Zahner Daniel, Haeberlein Simone, Moescheid Max F, Windhorst Anita, Burg-Roderfeld Monika, Glebe Dieter, Moreira Bernardo Pereira, Lesieur Céline, Schmid Andreas, Falcone Franco H, Grevelding Christoph G, Roeb Elke, Roderfeld Martin

The DEAD-box RNA helicase eIF4A is a crucial factor for stem-cell activity and reproduction of the parasite Schistosoma mansoni

DEAD-box RNA解旋酶eIF4A是曼氏血吸虫干细胞活性和繁殖的关键因子。

Welsch, Sophie; Puckelwaldt, Oliver; Ajmera, Sagar; Magari, Francesca; Haeberlein, Simone; Grünweller, Arnold; Grevelding, Christoph G

Bis-3-chloropiperidines: a novel motif for anthelmintic drug design

双-3-氯哌啶:一种新型的驱虫药物设计基序

Kirchner, Michael; Marner, Michael; Kramer, Tim; Mühlemeyer, Felix; Eichberg, Johanna; Oberpaul, Markus; Haeberlein, Simone; Göttlich, Richard

Antischistosomal Potential of Animal-Derived Natural Products and Compounds

动物源天然产物和化合物的抗血吸虫潜力

Fischer-Carvalho, Agatha; Taveira-Barbosa, Tereza Cristina; Verjovski-Almeida, Sergio; Haeberlein, Simone; Sena Amaral, Murilo

Extracellular Vesicles From Schistosoma mansoni Adult Worms Stimulate IL-10 Release by B Cells

曼氏血吸虫成虫的细胞外囊泡刺激B细胞释放IL-10

Kuipers, Marije E; Ozir-Fazalalikhan, Arifa; Haeberlein, Simone; Driessen, Nicole N; de Korne, Clarize M; Mes, Lynn; Hensbergen, Paul J; Nolte-'t Hoen, Esther N M; Hokke, Cornelis H; Smits, Hermelijn H

Spatial transcriptomics of a parasitic flatworm provides a molecular map of drug targets and drug resistance genes.

寄生扁形动物的空间转录组学提供了药物靶点和耐药基因的分子图谱

Gramberg Svenja, Puckelwaldt Oliver, Schmitt Tobias, Lu Zhigang, Haeberlein Simone