日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD Mice

生命早期出现β-淀粉样蛋白会引发5xFAD小鼠海马CA1区神经元过度兴奋、线粒体退化和树突复杂性丧失

Kelley, Amanda R; Sackinger, Emily; Frischman, Mathew; Thomas, Nicholas; Kim, Kaitlyn J; Scuderi, Grace; Labut, Edwin M; MacMurchy, Duncan; Ikea-Mario, Toren; Rauenhorst, Jacob; Neitzel, Easton; Vu, Tacita; Liko, Leda; Hoff, Alexandra; Hoff, Ashley; Wallace, Olivia; Harry, Wren K E; Hagen, Benjamin; Lee, Ken; Bihun, Alejandro Z; Abou-Seada, Ibrahim A; Butler, Judy A; Nigussie, Fikru; Ebrahimi, Arpa; Lee, Phoebe Y; Marney, Luke C; Maier, Claudia S; Magnusson, Kathy R; Hagen, Tory M

Supercomplex Organization of the Electron Transfer System in Marine Bivalves, a Model of Extreme Longevity

海洋双壳类动物电子传递系统的超复杂组织结构,是超长寿的典范

Rodríguez, Enrique; Radke, Amanda; Hagen, Tory M; Blier, Pierre U

A Randomized Controlled Trial of Long-Term (R)-α-Lipoic Acid Supplementation Promotes Weight Loss in Overweight or Obese Adults without Altering Baseline Elevated Plasma Triglyceride Concentrations

一项随机对照试验表明,长期补充(R)-α-硫辛酸可促进超重或肥胖成年人的体重减轻,且不会改变基线升高的血浆甘油三酯浓度。

Bobe, Gerd; Michels, Alexander J; Zhang, Wei-Jian; Purnell, Jonathan Q; Woffendin, Clive; Pereira, Cliff; Vita, Joseph A; Thomas, Nicholas O; Traber, Maret G; Frei, Balz; Hagen, Tory M

Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica

先前与物种最大寿命相关的线粒体特征与双壳类北极蛤(Arctica islandica)不同种群的寿命并不相关。

Rodríguez, Enrique; Dégletagne, Cyril; Hagen, Tory M; Abele, Doris; Blier, Pierre U

Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function

人类遗传变异通过改变维生素C的转运和抗氧化酶的功能来影响维生素C的稳态。

Michels, Alexander J; Hagen, Tory M; Frei, Balz

Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?

与年龄相关的线粒体生物能量学衰退:超复合物不稳定是否会导致氧化能力下降和超氧化物产生增加?

Gómez, Luis A; Hagen, Tory M

A rat primary hepatocyte culture model for aging studies

用于衰老研究的大鼠原代肝细胞培养模型

Shenvi, Swapna V; Dixon, Brian M; Petersen Shay, Kate; Hagen, Tory M

Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis

p75神经营养因子受体诱导的运动神经元凋亡中线粒体超氧化物生成和核因子E2相关因子2激活

Pehar, Mariana; Vargas, Marcelo R; Robinson, Kristine M; Cassina, Patricia; Díaz-Amarilla, Pablo J; Hagen, Tory M; Radi, Rafael; Barbeito, Luis; Beckman, Joseph S

Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease

α-硫辛酸和乙酰左旋肉碱联合治疗对冠状动脉疾病患者血管功能和血压的影响

McMackin, Craig J; Widlansky, Michael E; Hamburg, Naomi M; Huang, Alex L; Weller, Susan; Holbrook, Monika; Gokce, Noyan; Hagen, Tory M; Keaney, John F Jr; Vita, Joseph A

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

Nrf2 转录活性的下降会导致与年龄相关的谷胱甘肽合成减少,而硫辛酸可以逆转这种减少

Suh Jung H, Shenvi Swapna V, Dixon Brian M, Liu Honglei, Jaiswal Anil K, Liu Rui-Ming, Hagen Tory M