日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer

HIV-1包膜的突变增强了病毒与猕猴CD4受体的结合,并通过破坏三聚体内部的四级相互作用来改变抗体识别。

Boyd, David F; Peterson, Dylan; Haggarty, Beth S; Jordan, Andrea P O; Hogan, Michael J; Goo, Leslie; Hoxie, James A; Overbaugh, Julie

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.

猿猴免疫缺陷病毒包膜胞质尾部酪氨酸依赖性运输基序的缺失不会影响粘膜 CD4 细胞,但不会阻止疾病进展

Breed Matthew W, Jordan Andrea P O, Aye Pyone P, Lichtveld Cornelis F, Midkiff Cecily C, Schiro Faith R, Haggarty Beth S, Sugimoto Chie, Alvarez Xavier, Sandler Netanya G, Douek Daniel C, Kuroda Marcelo J, Pahar Bapi, Piatak Michael Jr, Lifson Jeffrey D, Keele Brandon F, Hoxie James A, Lackner Andrew A