日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions

GOLGA8A基因的重复扩增是伴有泛素阳性包涵体的非典型额颞叶变性的主要风险因素。

De Coster, Wouter; Van den Broeck, Marleen; Baker, Matt; Ghayal, Nikhil B; Wynants, Sarah; Batzler, Anthony; Pottier, Cyril; Alidadiani, Sara; Küçükali, Fahri; Jenkins, Gregory D; Policarpo, Rafaela; van Blitterswijk, Marka; DeJesus-Hernandez, Mariely; Soto-Beasley, Alexandra I; Faura, Júlia; Coopman, Elise; Hutten, Saskia; Mol, Merel O; Wallon, David; Sieben, Anne; Finger, Elizabeth C; Murray, Melissa E; Forrest, Shelley L; Tartaglia, Maria C; Troakes, Claire; van Rooij, Jeroen G J; Nguyen, Aivi T; Reichard, R Ross; Woodman, Natalie L; Nana, Alissa L; Weintraub, Sandra; Gefen, Tamar; De Vil, Bart; Bodi, Istvan; Lopez, Oscar L; Boluda, Susana; Belliard, Serge; Lebert, Florence; Marguet, Florent; Mao, Qinwen; Mesulam, Marsel M; Boxer, Adam L; Vandenbulcke, Mathieu; Suh, EunRan; Schaeverbeke, Jolien; Lambert, Jean-Charles; Scholz, Sonja W; Dalgard, Clifton L; Traynor, Bryan J; Gibbs, Raphael J; Schellenberg, Gerard D; Dormann, Dorothee; Joris, Geert; De Pooter, Tim; De Rijk, Peter; D'Hert, Svenn; Van Dongen, Jasper; van der Zee, Julie; Strazisar, Mojca; Gearing, Marla; Kukar, Thomas; Flanagan, Margaret; Engelborghs, Sebastiaan; Ghetti, Bernardino; Newell, Kathy L; King, Andrew; Roeber, Sigrun; Rosen, Howard J; Spina, Salvatore; Cras, Patrick; Ertekin-Taner, Nilüfer; Wszolek, Zbigniew K; Uitti, Ryan J; Cheshire, William P; Singer, Wolfgang; Herms, Jochen; Josephs, Keith A; Whitwell, Jennifer L; Petersen, Ronald C; Pasquier, Florence; Nicolas, Gaël; Castellani, Rudolph; Glass, Jonathan; Miller, Bruce L; Kovacs, Gabor G; Rissman, Robert A; Hiniker, Annie; Deramecourt, Vincent; Ang, Lee-Cyn; Lee-Way, Jin; Van Deerlin, Vivianna M; Dugger, Brittany N; Thal, Dietmar R; Grinberg, Lea T; Cruchaga, Carlos; Arzberger, Thomas; Munoz, David G; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Lee, Edward B; Haggarty, Stephen J; Ansorge, Olaf; Husain, Masud; Halliday, Glenda M; Al-Sarraj, Safa; Ross, Owen A; Sleegers, Kristel; Vandenberghe, Rik; Boeve, Bradley F; Graff-Radford, Neill R; Kofler, Julia; White, Charles L 3rd; Lashley, Tammaryn; Neumann, Manuela; Biernacka, Joanna M; Seeley, William W; Seelaar, Harro; van Swieten, John C; Rohrer, Jonathan D; Dickson, Dennis W; Mackenzie, Ian R A; Rademakers, Rosa

Correction: Discovery and optimization of tau targeted protein degraders enabled by patient induced pluripotent stem cells-derived neuronal models of tauopathy

更正:利用患者诱导多能干细胞衍生的tau蛋白病神经元模型,发现了靶向tau蛋白降解剂并对其进行了优化。

Silva, M Catarina; Nandi, Ghata; Donovan, Katherine A; Cai, Quan; Berry, Bethany C; Nowak, Radoslaw P; Fischer, Eric S; Gray, Nathanael S; Ferguson, Fleur M; Haggarty, Stephen J

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

发现能够调控AP-1转录因子ΔFOSB的DNA结合和释放的小分子和可成药沟槽

McNeme, Sean; Yim, Yun Young; Kumar, Ashwani; Li, Yi; Hughes, Brandon; St Romain, Corey Peyton; Aglyamova, Galina; Chen, Jianping; Nguyen, Nghi D; Fan, Shanghua; Stephens, Gabriel S; Zhao, Wen-Ning; Kruzshak, Samantha; Estill, Molly; Brener, Corrine; Tofani, Solange; Kumar, Anil; Chen, Earnest P; Takatka, Nadeen; Robison, Alfred J; Chen, Haiying; Powell, Reid T; Haggarty, Stephen J; Stephan, Clifford; Nestler, Eric J; Chin, Jeannie; Machius, Mischa; Zhou, Jia; Rudenko, Gabby

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

通过全基因组测序解析FTLD-TDP病理亚型的不同遗传风险因素

Pottier, Cyril; Küçükali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D; van Blitterswijk, Marka; Vicente, Cristina T; De Coster, Wouter; Wynants, Sarah; Van de Walle, Pieter; Ross, Owen A; Murray, Melissa E; Faura, Júlia; Haggarty, Stephen J; van Rooij, Jeroen Gj; Mol, Merel O; Hsiung, Ging-Yuek R; Graff, Caroline; Öijerstedt, Linn; Neumann, Manuela; Asmann, Yan; McDonnell, Shannon K; Baheti, Saurabh; Josephs, Keith A; Whitwell, Jennifer L; Bieniek, Kevin F; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G; Yokoyama, Jennifer S; Oddi, Alexis P; Flanagan, Margaret; Mao, Qinwen; Hodges, John R; Kwok, John B; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C; Evers, Bret M; Dugger, Brittany N; Munoz, David G; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, EunRan; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R; Edbauer, Dieter; Woodruff, Bryan K; Caselli, Richard J; Donker Kaat, Laura L; Huey, Edward D; Reiman, Eric M; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L; Ertekin-Taner, Nilufer; Knopman, David S; Petersen, Ronald C; Petrucelli, Leonard; Uitti, Ryan J; Wszolek, Zbigniew K; Ramos, Eliana Marisa; Grinberg, Lea T; Tempini, Maria Luisa Gorno; Rosen, Howard J; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q; Keene, C Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H; Rissman, Robert A; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M; Beach, Thomas G; Serrano, Geidy E; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L; Honig, Lawrence S; Vonsattel, Jean P; Lopez, Oscar L; Kofler, Julia; White, Charles L 3rd; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D; Irwin, David J; Lee, Edward B; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M; Tartaglia, Maria C; Finger, Elizabeth C; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L; Miller, Bruce L; Seelaar, Harro; Graff-Radford, Neill R; Boeve, Bradley F; Mackenzie, Ian Ra; van Swieten, John C; Seeley, William W; Sleegers, Kristel; Dickson, Dennis W; Biernacka, Joanna M; Rademakers, Rosa

Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond

利用双功能分子靶向降解蛋白质作为治疗阿尔茨海默病及其他疾病的新型疗法

Sandhof, C Alexander; Murray, Heide F B; Silva, M Catarina; Haggarty, Stephen J

Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders

深度学习增强了对脑活动图谱的解读,有助于发现治疗脑部疾病的方法

Zhang, Xianrui; Liu, Zhen; Luo, Xuan; Cao, Yi; Zhang, Wencong; Li, Honglin; Li, Wei; Cheng, Shuk Han; Haggarty, Stephen J; Wang, Xin; Shi, Peng

MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies

MAPT剪接调节剂作为tau蛋白病的一种治疗策略

Silva, M Catarina; Lindmeier, Hannah; Pigini, Paolo; Laughlin, Jennifer; Yu, Yong; Morrill, Christie; Arnold, Michael A; Barraza, Scott J; Saadipour, Khalil; Dieterich, Monal; Minnella, Angela; Datta, Kausiki; Zhang, Nanjing; Narasimhan, Jana; Trotta, Christopher R; Woll, Matthew G; Welch, Ellen M; Benzow, Kellie; Karanjeet, Kul; Lotz, Steven; Bertucci, Taylor; Temple, Sally; Haggarty, Stephen J; Koob, Michael; Trimmer, Jeffrey; Weetall, Marla; Morini, Elisabetta

Environmental impact, cost, and acceptability of a laboratory sustainability certification program for biomedical research in an academic medical center

学术医疗中心生物医学研究实验室可持续性认证项目的环境影响、成本和可接受性分析

Padget, Michael; Sörme, Pernilla; Spezia, Michael; Slaugenhaupt, Susan A; McKowen, James; Kirchner, Emily; Ameral, Natalie; Reis, Surya A; Slater, Damien; Haggarty, Stephen J; Kleinstiver, Benjamin P; Dunn, Erin C; Larocque, Regina; Alves, Christiano R R; Stern, Max; Pelli, Alida; Duhaime, Ann-Christine

Few-shot meta-learning applied to whole brain activity maps improves systems neuropharmacology and drug discovery

将少样本元学习应用于全脑活动图谱,可改进系统神经药理学和药物发现。

Luo, Xuan; Ding, Yanyun; Cao, Yi; Liu, Zhen; Zhang, Wenchong; Zeng, Shangzhi; Cheng, Shuk Han; Li, Honglin; Haggarty, Stephen J; Wang, Xin; Zhang, Jin; Shi, Peng

Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca(2+) entry and accelerated differentiation

双相情感障碍患者来源的诱导多能干细胞(iPSC)衍生的神经祖细胞表现出储存操纵性钙离子内流失调和分化加速。

Hewitt, Tristen; Alural, Begüm; Tilak, Manali; Wang, Jennifer; Becke, Natalina; Chartley, Ellis; Perreault, Melissa; Haggarty, Stephen J; Sheridan, Steven D; Perlis, Roy H; Jones, Nina; Mellios, Nikolaos; Lalonde, Jasmin