日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cardiotropic AAV gene therapy for heart failure: a phase 1 trial

针对心力衰竭的心脏靶向性AAV基因疗法:一项I期试验

Henry, Timothy D; Chung, Eugene S; Alvisi, Monica; Sethna, Ferzin; Murray, David R; Traverse, Jay H; Roessig, Lothar; Roberts, Luke; Reddy, Swarna; Chen, Youjun; Ozkan, Tugba Guven; Webb, Stacy; Mittal, Monika; Ervin, Leigh; Sadek, Hesham; Mikhail, Sheila; Haghighi, Kobra; Jiang, Canwen; Samulski, R Jude; Kranias, Evangelia G; Tretiakova, Anna P; Hajjar, Roger J

Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts

心律失常磷蛋白-R14del人源化小鼠心脏心室动作电位调节蛋白的亚型变化

Rogalska, Malgorzata E; Vafiadaki, Elizabeth; Erpapazoglou, Zoi; Haghighi, Kobra; Green, Lisa; Mantzoros, Christos S; Hajjar, Roger J; Tranter, Michael; Karakikes, Ioannis; Kranias, Evangelia G; Stillitano, Francesca; Kafasla, Panagiota; Sanoudou, Despina

Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact

基因编辑逆转人源化PLN-R14del小鼠的心律失常易感性:模拟一种具有全球影响的欧洲心肌病

Dave, Jaydev; Raad, Nour; Mittal, Nishka; Zhang, Lu; Fargnoli, Anthony; Oh, Jae Gyun; Savoia, Maria Elisabetta; Hansen, Jens; Fava, Marika; Yin, Xiaoke; Theofilatos, Konstantinos; Ceholski, Delaine; Kohlbrenner, Erik; Jeong, Dongtak; Wills, Lauren; Nonnenmacher, Mathieu; Haghighi, Kobra; Costa, Kevin D; Turnbull, Irene C; Mayr, Manuel; Cai, Chen-Leng; Kranias, Evangelia G; Akar, Fadi G; Hajjar, Roger J; Stillitano, Francesca

Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca(2+) Handling and Arrhythmogenesis

PLN-R14del 蛋白异常相互作用增强 SERCA2a 抑制,导致 Ca(2+) 处理受损和心律失常。

Vafiadaki, Elizabeth; Haghighi, Kobra; Arvanitis, Demetrios A; Kranias, Evangelia G; Sanoudou, Despina

Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias.

右心室钙循环受损是 R14del-磷蛋白心律失常的早期危险因素

Haghighi Kobra, Gardner George, Vafiadaki Elizabeth, Kumar Mohit, Green Lisa C, Ma Jianyong, Crocker Jeffrey S, Koch Sheryl, Arvanitis Demetrios A, Bidwell Phillip, Rubinstein Jack, van de Leur Rutger, Doevendans Pieter A, Akar Fadi G, Tranter Michael, Wang Hong-Sheng, Sadayappan Sakthivel, DeMazumder Deeptankar, Sanoudou Despina, Hajjar Roger J, Stillitano Francesca, Kranias Evangelia G

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia

一种新型的人类R25C-磷蛋白突变与钙循环超抑制和室性心律失常有关

Liu, Guan-Sheng; Morales, Ana; Vafiadaki, Elizabeth; Lam, Chi Keung; Cai, Wen-Feng; Haghighi, Kobra; Adly, George; Hershberger, Ray E; Kranias, Evangelia G

Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility

人类衰竭心脏中microRNA765的上调与蛋白磷酸酶抑制剂-1的转录后调控和收缩力下降有关。

Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung; Florea, Stela; Qian, Jiang; Zhao, Wen; Pritchard, Tracy; Haghighi, Kobra; Lebeche, Djamel; Lu, Long Jason; Deng, Jingyuan; Fan, Guo-Chang; Hajjar, Roger J; Kranias, Evangelia G

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias

人类G109E抑制剂-1损害心脏功能并促进心律失常

Haghighi, Kobra; Pritchard, Tracy J; Liu, Guan-Sheng; Singh, Vivek P; Bidwell, Philip; Lam, Chi Keung; Vafiadaki, Elizabeth; Das, Parthib; Ma, Jianyong; Kunduri, Swati; Sanoudou, Despina; Florea, Stela; Vanderbilt, Erica; Wang, Hong-Shang; Rubinstein, Jack; Hajjar, Roger J; Kranias, Evangelia G

Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend

磷蛋白相互作用组在心脏收缩力和存活中的作用:老朋友的新视角

Haghighi, Kobra; Bidwell, Philip; Kranias, Evangelia G

Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts

活性抑制剂-1维持衰老心脏中的蛋白质过度磷酸化,并阻止衰竭心脏的重塑。

Pritchard, Tracy J; Kawase, Yoshiaki; Haghighi, Kobra; Anjak, Ahmad; Cai, Wenfeng; Jiang, Min; Nicolaou, Persoulla; Pylar, George; Karakikes, Ioannis; Rapti, Kleopatra; Rubinstein, Jack; Hajjar, Roger J; Kranias, Evangelia G