日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates.

在非人灵长类动物中快速诱导产生针对 HIV-1 Env V3 糖表位的 Asn332 糖基化非依赖性中和抗体。

Relano-Rodriguez Ignacio, Du Jianqiu, Lin Zi Jie, Kerwin Margaret, Tarquis-Medina Marta, Urbano Eduardo, Cui Jiayan, Watkins Meagan, Lavine Christy L, Zhao Peng, Habib Rumi, Agostino Colby, Ghosh Sukanya, Park Joyce, Boroughs Caroline, Walsh Agnes A, Melo Mariane B, Shukla Niharika, Shaw George M, Hahn Beatrice H, Irvine Darrell J, Wells Lance, Weiner David B, Seaman Michael S, Kulp Daniel W, Veazey Ronald S, Pallesen Jesper, Escolano Amelia

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization

单次注射免疫后,恒河猴V2顶端敲入小鼠模型迅速获得HIV-1中和广度

Ghosh, Amrit Raj; Habib, Rumi; Mishra, Nitesh; Roark, Ryan S; Akauliya, Madhav; Albowaidey, Ali A; Allen, Joel D; Amereh, Khaled; Avillion, Gabriel; Bottermann, Maria; Liang, Bo; Chaudhary, Namit; Callaghan, Sean; Dye, Jonathan; Li, Xuduo; Ellis-Pugh, Jordan R; Roy Chowdhury, Rohan; James, Nicole E; Liu, Xiaotie; Maiorino, Laura; Villavicencio, Paula M; Nedellec, Rebecca; Oberoi, Prabhgun; Sowers, Kirsten J; Park, Younghoon; Prum, Thavaleak; Rodriguez, Linette; Ssozi, Maria; Torres, Jonathan L; Walsh, Agnes A; Warner, John E; Weldon, Stephanie R; Xu, Liling; Wiehe, Kevin; Crispin, Max; Ward, Andrew B; Nair, Usha; Hahn, Beatrice H; Burton, Dennis R; Shapiro, Lawrence; Kwong, Peter D; Irvine, Darrell J; Andrabi, Raiees; Shaw, George M; Batista, Facundo D

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Targeted Chromosomal Sequencing of Wild Bonobos Identifies a Genetically Distinct Subpopulation East of the Lomami River

对野生倭黑猩猩进行靶向染色体测序,在洛马米河以东发现了一个遗传上独特的亚种群。

Crego-Walters, Mar; Cuadros-Espinoza, Sebastian; Ruiz-Gartzia, Irune; Han, Sojung; Hermosilla, Nuria; Helsen, Philippe; Frandsen, Peter; Prats, Alexandra Maria Brumwell; Alentorn-Moron, Pol; Fontsere, Claudia; Estape, Marina Alvarez; Ngofuna, Muzungu; Monghiemo, Claude; Leendertz, Fabian; Thompson, Jo; Fasbender, David; Dieguez, Paula; Lokasola, Albert Lotana; Brand, Colin; Ndjango, Jean-Bosco; Georgiev, Alexander V; Giles, Jasmin A; Liu, Weimin; Li, Yingying; Sharp, Paul M; Pereboom, Zjef; Andrés, Aida M; Kuhlwilm, Martin; Gronau, Ilan; Kuehl, Hjalmar; Wessling, Erin G; Narat, Victor; Surbeck, Martin; Hart, John A; Hart, Terese B; Hvilsom, Christina; Krutzen, Michael; Stevens, Jeroen; Hahn, Beatrice H; Lizano, Esther; Prado-Martinez, Javier; Marques-Bonet, Tomas

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.

早期克隆优势决定了 HIV 血清中和的广泛进程。

Liang Bo, Zhu Yuxin, Roark Ryan S, Li Xuduo, Mishra Nitesh, Martella Christian L, Vo Anh L, Giese Gabriella, Huang Qin, Biju Andrea, Tjio Lifei, Chowdhury Rohan Roy, Oberoi Prabhgun, Amereh Khaled, Wani Areeba A, Zhang Yuexiu, Andrabi Sharaf, Sekar Tharunika V, Somanathan Anjali, Kassab Muzaffer, Nedellec Rebecca, Callaghan Sean, Avillion Gabriel, Lewis Mark G, Sackett Sara Dutton, Skelly Ashwin N, Bibollet-Ruche Frederic, Shapiro Lawrence, Sheng Zizhang, Briney Bryan, Hahn Beatrice H, Burton Dennis R, Irvine Darrell J, Kwong Peter D, Shaw George M, Andrabi Raiees

Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.

短暂的聚糖屏障减少可诱导 SHIV 感染的猕猴产生 CD4 结合位点广谱中和抗体

Morris Daniel J, Gorman Jason, Zhou Tongqing, Lora Jinery, Connell Andrew J, Li Hui, Liu Weimin, Roark Ryan S, Campion Mary S, Carey John W, Habib Rumi, Li Yingying, Martella Christian L, Park Younghoon, Singh Ajay, Sowers Kirsten J, Teng I-Ting, Wang Shuyi, Chohan Neha, Ding Wenge, Lauer Craig, Lewis Emily, Mason Rosemarie D, Rando Juliette M, Peyton Lowrey, Schramm Chaim A, Wagh Kshitij, Korber Bette, Seaman Michael S, Douek Daniel C, Haynes Barton F, Kulp Daniel W, Roederer Mario, Hahn Beatrice H, Kwong Peter D, Shaw George M

Status of HIV vaccine development: progress and promise

艾滋病疫苗研发现状:进展与前景

Haynes, Barton F; Saunders, Kevin O; Hahn, Beatrice H; Wiehe, Kevin; Baden, Lindsey R; Shaw, George M

The HIV-1 envelope cytoplasmic tail protects infected cells from ADCC by downregulating CD4

HIV-1包膜胞质尾通过下调CD4来保护受感染细胞免受ADCC攻击。

Tauzin, Alexandra; Bélanger, Étienne; Prévost, Jérémie; Medjahed, Halima; Bourassa, Catherine; Bibollet-Ruche, Frederic; Richard, Jonathan; Hahn, Beatrice H; Finzi, Andrés

Plasmodium falciparum CyRPA Glycan Binding Does Not Explain Adaptation to Humans

恶性疟原虫 CyRPA 糖基化结合并不能解释其对人类的适应性。

Sharp, Paul M; Bibollet-Ruche, Frederic; Hahn, Beatrice H

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

对人类抗体库的深度挖掘发现了可通过疫苗接种靶向的常见且遗传多样性丰富的CDRH3拓扑结构

Habib, Rumi; Solieva, Shahlo O; Lin, Zi Jie; Ghosh, Sukanya; Bayruns, Kelly; Singh, Maya; Agostino, Colby J; Tursi, Nicholas J; Sowers, Kirsten J; Huang, Jinwei; Roark, Ryan S; Purwar, Mansi; Park, Younghoon; Ayyanathan, Kasirajan; Li, Hui; Carey, John W; Kim, Amber; Park, Joyce; McCanna, Madison E; Skelly, Ashwin N; Chokkalingam, Neethu; Kriete, Sinja; Shupin, Nicholas; Huynh, Alana; Walker, Susanne; Sadeesh, Roopak; Laenger, Niklas; Du, Jianqiu; Cui, Jiayan; Patel, Ami; Escolano, Amelia; Kwong, Peter D; Shapiro, Lawrence; Bowman, Gregory R; Hahn, Beatrice H; Shaw, George M; Weiner, David B; Pallesen, Jesper; Kulp, Daniel W