日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma

利用开放科学药物发现模型开发中枢神经系统渗透性 ALK2 抑制剂,用于治疗弥漫性内在性脑桥胶质瘤

David Smil, Jong Fu Wong, Eleanor P Williams, Roslin J Adamson, Alison Howarth, David A McLeod, Ahmed Mamai, Soyoung Kim, Brian J Wilson, Taira Kiyota, Ahmed Aman, Julie Owen, Gennady Poda, Kurumi Y Horiuchi, Ekaterina Kuznetsova, Haiching Ma, J Nicole Hamblin, Sue Cramp, Owen G Roberts, Aled M Edwa

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

利用核小体底物进行高通量筛选,鉴定出人类组蛋白赖氨酸甲基转移酶 NSD2 的小分子抑制剂

Nathan P Coussens, Stephen C Kales, Mark J Henderson, Olivia W Lee, Kurumi Y Horiuchi, Yuren Wang, Qing Chen, Ekaterina Kuznetsova, Jianghong Wu, Sirisha Chakka, Dorian M Cheff, Ken Chih-Chien Cheng, Paul Shinn, Kyle R Brimacombe, Min Shen, Anton Simeonov, Madhu Lal-Nag, Haiching Ma, Ajit Jadhav, Ma

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

通过依布硒及其类似物开发选择性组蛋白去乙酰化酶 (HDAC) 抑制剂

Yuren Wang, Jason Wallach, Stephanie Duane, Yuan Wang, Jianghong Wu, Jeffrey Wang, Adeboye Adejare, Haiching Ma

Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases

激酶抑制剂分析揭示了抑制疾病相关突变激酶的意外机会

Krisna C Duong-Ly, Karthik Devarajan, Shuguang Liang, Kurumi Y Horiuchi, Yuren Wang, Haiching Ma, Jeffrey R Peterson

Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor

非骨髓抑制性 Janus 激酶 2 抑制剂帕克替尼的综合激酶概况

Jack W Singer, Suliman Al-Fayoumi, Haiching Ma, Rami S Komrokji, Ruben Mesa, Srdan Verstovsek

Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors

DFG-out 激酶基序的构象分析和经过结构验证的 II 型抑制剂的生化分析

R S K Vijayan, Peng He, Vivek Modi, Krisna C Duong-Ly, Haiching Ma, Jeffrey R Peterson, Roland L Dunbrack Jr, Ronald M Levy

Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases

开发和使用适合于筛选和分析 SET 域靶向 MLL/SET1 赖氨酸甲基转移酶家族抑制剂的检测条件

Joseph J Ferry, Robert F Smith, Natalie Denney, Colin P Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y Horiuchi, Konrad T Howitz

Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases

鉴定具有苯甲酰肼骨架的组蛋白去乙酰化酶抑制剂,其可选择性抑制 I 类组蛋白去乙酰化酶

Yunfei Wang, Ryan L Stowe, Christie E Pinello, Guimei Tian, Franck Madoux, Dawei Li, Lisa Y Zhao, Jian-Liang Li, Yuren Wang, Yuan Wang, Haiching Ma, Peter Hodder, William R Roush, Daiqing Liao

Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK

索拉非尼通过抑制ZAK来抑制JNK依赖性细胞凋亡。

Vin, Harina; Ching, Grace; Ojeda, Sandra S; Adelmann, Charles H; Chitsazzadeh, Vida; Dwyer, David W; Ma, Haiching; Ehrenreiter, Karin; Baccarini, Manuela; Ruggieri, Rosamaria; Curry, Jonathan L; Ciurea, Ana M; Duvic, Madeleine; Busaidy, Naifa L; Tannir, Nizar M; Tsai, Kenneth Y

Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis

选择性小分子胱天蛋白酶抑制剂对星形孢菌素诱导的细胞凋亡的细胞保护作用

Jianghong Wu, Yuren Wang, Shuguang Liang, Haiching Ma