日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

KRASG12R突变型胰腺癌具有ERK/MAPK转录活性受限和独特的肿瘤微环境。

Burge, Rachel A; Le Roux, Ozgun; Popow, Olesja; Spadafora, Victoria K; Rajesh, Christabelle; Adair, Sara J; Bialousow, Lucas; Murphy, Cailey; Saberi, Samaneh; Vaena, Silvia G; Taquey, Margaret C; Allen, Sarah; Han, Lu; Helke, Kristi L; Sharma, Sudarshana; Ostrowski, Michael C; Guttridge, Denis C; Dincman, Toros A; Bauer, Todd W; Kashatus, David F; McFall, Thomas; Haigis, Kevin M; Hollingsworth, Michael A; Counter, Christopher M; Der, Channing J; Hobbs, G Aaron

The Neomorphic Chemistry of KRAS Autophosphorylation Is Dynamically Regulated by Active Site Conformation

KRAS自磷酸化的新型化学机制受活性位点构象的动态调控

Johnson, Christian W; Oladimeji, Rofiat; O'Donohue, Eve; Haigis, Kevin M

The network response to Egf is tissue-specific.

网络对 EGF 的反应具有组织特异性

Awasthi Beatrice W, Paulo João A, Burkhart Deborah L, Smith Ian R, Collins Ryan L, Harper J Wade, Gygi Steven P, Haigis Kevin M

Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras

c-Myc 的基础表达决定了致癌 K-Ras 的组织特异性

Popow, Olesja; Yu, Qing; Yapp, Clarance; Hull, Shannon; Paulo, João A; Hanna, Benjamin; Xu, Shidong; Kuang, Yanan; Sigel, Carlie; Paweletz, Cloud P; Gygi, Steven P; Haigis, Kevin M

Effects of KRAS Genetic Interactions on Outcomes in Cancers of the Lung, Pancreas, and Colorectum

KRAS基因相互作用对肺癌、胰腺癌和结直肠癌预后的影响

Grabski, Isabella N; Heymach, John V; Kehl, Kenneth L; Kopetz, Scott; Lau, Ken S; Riely, Gregory J; Schrag, Deborah; Yaeger, Rona; Irizarry, Rafael A; Haigis, Kevin M

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Switch-II结构域的变构调节控制KRAS致癌性

Yang, Moon Hee; Tran, Timothy H; Hunt, Bethany; Agnor, Rebecca; Johnson, Christian W; Shui, Bing; Waybright, Timothy J; Nowak, Jonathan A; Stephen, Andrew G; Simanshu, Dhirendra K; Haigis, Kevin M

Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention

KRAS激活突变的分类及其对治疗干预的意义

Johnson, Christian; Burkhart, Deborah L; Haigis, Kevin M

Interplay between K-RAS and miRNAs

K-RAS与miRNA之间的相互作用

Shui, Bing; La Rocca, Gaspare; Ventura, Andrea; Haigis, Kevin M

Acquired Resistance to KRAS(G12C) Inhibition in Cancer

癌症中对KRAS(G12C)抑制剂的获得性耐药

Awad, Mark M; Liu, Shengwu; Rybkin, Igor I; Arbour, Kathryn C; Dilly, Julien; Zhu, Viola W; Johnson, Melissa L; Heist, Rebecca S; Patil, Tejas; Riely, Gregory J; Jacobson, Joseph O; Yang, Xiaoping; Persky, Nicole S; Root, David E; Lowder, Kristen E; Feng, Hanrong; Zhang, Shannon S; Haigis, Kevin M; Hung, Yin P; Sholl, Lynette M; Wolpin, Brian M; Wiese, Julie; Christiansen, Jason; Lee, Jessica; Schrock, Alexa B; Lim, Lee P; Garg, Kavita; Li, Mark; Engstrom, Lars D; Waters, Laura; Lawson, J David; Olson, Peter; Lito, Piro; Ou, Sai-Hong I; Christensen, James G; Jänne, Pasi A; Aguirre, Andrew J

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

小鼠N-RasG12D棕榈酰化基因的破坏会扰乱造血过程并阻止髓系转化。

Zambetti, Noemi A; Firestone, Ari J; Remsberg, Jarrett R; Huang, Benjamin J; Wong, Jasmine C; Long, Amanda M; Predovic, Marina; Suciu, Radu M; Inguva, Anagha; Kogan, Scott C; Haigis, Kevin M; Cravatt, Benjamin F; Shannon, Kevin