日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification

脑脊液中亨廷顿蛋白检测的挑战与进展:支持相对定量

Rachel J Harding, Yuanyun Xie, Nicholas S Caron, Hailey Findlay-Black, Caroline Lyu, Nalini Potluri, Renu Chandrasekaran, Michael R Hayden, Blair R Leavitt, Douglas R Langbehn, Amber L Southwell

Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice

脑脊液突变亨廷顿蛋白是亨廷顿病小鼠纹状体中亨廷顿蛋白降低的生物标志物

Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayden

Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity

用于评估亨廷顿病发病和严重程度的脑脊液生物标志物

Nicholas S Caron, Arsalan S Haqqani, Akshdeep Sandhu, Amirah E Aly, Hailey Findlay Black, Jeffrey N Bone, Jodi L McBride, Abedelnasser Abulrob, Danica Stanimirovic, Blair R Leavitt, Michael R Hayden

Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease

亨廷顿病中的突变亨廷顿蛋白通过活性机制从大脑中清除

Nicholas S Caron, Raul Banos, Christopher Yanick, Amirah E Aly, Lauren M Byrne, Ethan D Smith, Yuanyun Xie, Stephen E P Smith, Nalini Potluri, Hailey Findlay Black, Lorenzo Casal, Seunghyun Ko, Daphne Cheung, Hyeongju Kim, Ihn Sik Seong, Edward J Wild, Ji-Joon Song, Michael R Hayden, Amber L Southwe

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

通过 AAV5 编码 miRNA 强效且持续地降低亨廷顿蛋白,在人源化亨廷顿病小鼠模型中保留纹状体体积和认知功能

Nicholas S Caron, Amber L Southwell, Cynthia C Brouwers, Louisa Dal Cengio, Yuanyun Xie, Hailey Findlay Black, Lisa M Anderson, Seunghyun Ko, Xiang Zhu, Sander J van Deventer, Melvin M Evers, Pavlina Konstantinova, Michael R Hayden

A competence-regulated toxin-antitoxin system in Haemophilus influenzae

流感嗜血杆菌中能力调节的毒素-抗毒素系统

Hailey Findlay Black, Scott Mastromatteo, Sunita Sinha, Rachel L Ehrlich, Corey Nislow, Joshua Chang Mell, Rosemary J Redfield

A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease

亨廷顿病等位基因特异性 HTT 抑制的综合单倍型靶向策略

Chris Kay, Jennifer A Collins, Nicholas S Caron, Luciana de Andrade Agostinho, Hailey Findlay-Black, Lorenzo Casal, Dulika Sumathipala, Vajira H W Dissanayake, Mario Cornejo-Olivas, Fiona Baine, Amanda Krause, Jacquie L Greenberg, Carmen Lúcia Antão Paiva, Ferdinando Squitieri, Michael R Hayden