Autologous bone marrow-derived MSCs engineered to express oFVIII-FLAG engraft in adult sheep and produce an effective increase in plasma FVIII levels
自体骨髓衍生 MSCs 经过改造,可表达 oFVIII-FLAG,植入成年绵羊体内,有效提高血浆 FVIII 水平
期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2022.1070476
Brady Trevisan, Martin Rodriguez, Hailey Medder, Shannon Lankford, Rebecca Combs, John Owen, Anthony Atala, Christopher D Porada, Graça Almeida-Porada