日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

细胞类型特异性转录组学揭示突变亨廷顿蛋白导致线粒体 RNA 释放和神经元先天免疫激活

Hyeseung Lee, Robert J Fenster, S Sebastian Pineda, Whitney S Gibbs, Shahin Mohammadi, Jose Davila-Velderrain, Francisco J Garcia, Martine Therrien, Hailey S Novis, Fan Gao, Hilary Wilkinson, Thomas Vogt, Manolis Kellis, Matthew J LaVoie, Myriam Heiman

Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

GBA1 突变星形胶质细胞中的溶酶体和炎症缺陷可通过 LRRK2 抑制恢复正常

Anwesha Sanyal, Mark P DeAndrade, Hailey S Novis, Steven Lin, Jianjun Chang, Nathalie Lengacher, Julianna J Tomlinson, Malú G Tansey, Matthew J LaVoie

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

LRRK2 激酶抑制可挽救人类 iPSC 衍生神经元中杂合 GBA1 表达导致的溶酶体功能缺陷

Anwesha Sanyal, Hailey S Novis, Emile Gasser, Steven Lin, Matthew J LaVoie