The cGAS-STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts
cGAS-STING、p38 MAPK 和 p53 通路将基因组不稳定性与 ATM 缺陷小鼠肺成纤维细胞的加速衰老联系起来。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2419196122
Haj, Majd; Frey, Yann; Levon, Amit; Maliah, Avishai; Ben-Yishay, Tal; Slutsky, Rachel; Smoom, Riham; Tzfati, Yehuda; Ben-David, Uri; Levy, Carmit; Elkon, Ran; Ziv, Yael; Shiloh, Yosef
成纤维细胞
p38 MAPK
信号转导
STING
cGAS-STING
MAPK/ERK
ATM
衰老
细胞生物学