日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt

肝脏 BRCA1 通过调节 BHMT 产生矛盾的致癌作用

Ghebreselassie, Martha; Park, Yoo Jin; Nakib, Diana; Dodington, David; Patel, Parasvi; Won, Sohyun; Hakem, Anne; Hakem, Razqallah; MacParland, Sonya; Woo, Minna

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

泛素连接酶RNF8抑制Notch信号通路以调控乳腺发育和肿瘤发生

Li, Li; Guturi, Kiran Kumar Naidu; Gautreau, Brandon; Patel, Parasvi S; Saad, Amine; Morii, Mayako; Mateo, Francesca; Palomero, Luis; Barbour, Haithem; Gomez, Antonio; Ng, Deborah; Kotlyar, Max; Pastrello, Chiara; Jackson, Hartland W; Khokha, Rama; Jurisica, Igor; Affar, El Bachir; Raught, Brian; Sanchez, Otto; Alaoui-Jamali, Moulay; Pujana, Miguel A; Hakem, Anne; Hakem, Razq

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

RNF168泛素化53BP1并控制其对DNA双链断裂的反应

Bohgaki, Miyuki; Bohgaki, Toshiyuki; El Ghamrasni, Samah; Srikumar, Tharan; Maire, Georges; Panier, Stephanie; Fradet-Turcotte, Amélie; Stewart, Grant S; Raught, Brian; Hakem, Anne; Hakem, Razqallah

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice

在Bim-/-小鼠中,T细胞中Caspase-8的失活会增加坏死性凋亡并抑制自身免疫。

Bohgaki, Toshiyuki; Mozo, Julien; Salmena, Leonardo; Matysiak-Zablocki, Elzbieta; Bohgaki, Miyuki; Sanchez, Otto; Strasser, Andreas; Hakem, Anne; Hakem, Razqallah

Role of Pirh2 in mediating the regulation of p53 and c-Myc

Pirh2在介导p53和c-Myc调控中的作用

Hakem, Anne; Bohgaki, Miyuki; Lemmers, Bénédicte; Tai, Elisabeth; Salmena, Leonardo; Matysiak-Zablocki, Elzbieta; Jung, Yong-Sam; Karaskova, Jana; Kaustov, Lilia; Duan, Shili; Madore, Jason; Boutros, Paul; Sheng, Yi; Chesi, Marta; Bergsagel, P Leif; Perez-Ordonez, Bayardo; Mes-Masson, Anne-Marie; Penn, Linda; Squire, Jeremy; Chen, Xinbin; Jurisica, Igor; Arrowsmith, Cheryl; Sanchez, Otto; Benchimol, Samuel; Hakem, Razqallah

Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis

Pirh2 E3泛素连接酶对DNA聚合酶η进行单泛素化修饰,从而抑制跨损伤DNA合成。

Jung, Yong-Sam; Hakem, Anne; Hakem, Razqallah; Chen, Xinbin

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

RhoC对于胚胎发生和肿瘤起始并非必需,但对于转移至关重要。

Hakem, Anne; Sanchez-Sweatman, Otto; You-Ten, Annick; Duncan, Gordon; Wakeham, Andrew; Khokha, Rama; Mak, Tak W

Collaboration of Brca1 and Chk2 in tumorigenesis.

Brca1 和 Chk2 在肿瘤发生中的协同作用

McPherson John Peter, Lemmers Bénédicte, Hirao Atsushi, Hakem Anne, Abraham Jacinth, Migon Eva, Matysiak-Zablocki Elzbieta, Tamblyn Laura, Sanchez-Sweatman Otto, Khokha Rama, Squire Jeremy, Hande M Prakash, Mak Tak W, Hakem Razqallah