日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.

TH5487 专门针对对 MCC950 耐药的 FCAS 患者中的 NLRP3。

Lackner Angela, Picucci Sofia I, Jiang Wenjin, Onyuru Janset, Campos Melissa, Cabral Julia E, Leonidas Lemuel, Macapagal Alijah, Lee Hannah, Henriquez Valerie, Wang Karen, Xu Huilin, Qiu Yanfei, Albrecht Lauren V, Hoffman Hal M, McNulty Reginald

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

利用反义寡核苷酸调控NLRP3剪接以控制病理性炎症

Klein, Roni; Onyuru, Janset; Centa, Jessica L; Viera, Estela M; Putnam, Christopher D; Hoffman, Hal M; Hastings, Michelle L

Development of a Mouse Model of Coccidioidomycosis Using an Inhalation Exposure System.

利用吸入暴露系统建立球孢子菌病小鼠模型

Erlich Jonathan Rodrigo, Rodriguez Priscila, Yau Ka Pui Sharon, Tate Matthew, Carlin Aaron F, Fierer Joshua, Kirkland Theo N, Hoffman Hal M, Beyhan Sinem, Croker Ben A

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome

牛磺酸水平的兴奋性升高可通过抑制NLRP3炎症小体来抑制炎症衰老。

Guan, Chenyang; Ryu, Seungjin; Dong, Mingze; Youm, Yun-Hee; Mohanty, Subhasis; Maeda, Rae; Orliaguet, Lucie; Kim, Hee-Hoon; Dlugos, Tamara; Smith, Steven R; Ravussin, Eric; Onyuru, Janset; Wang, Andrew; Shaw, Albert C; Hoffman, Hal M; Kluger, Yuval; Sugiura, Yuki; Dixit, Vishwa Deep

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.

利用反义寡核苷酸调节 NLRP3 剪接以控制病理性炎症

Klein Roni, Onyuru Janset, Centa Jessica L, Viera Estela M, Duelli Fox J, Putnam Christopher D, Hoffman Hal M, Hastings Michelle L

Publisher Correction: IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

出版商更正:IL-1与自身炎症性疾病:生物学、发病机制和治疗靶点

Broderick, Lori; Hoffman, Hal M

The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity

NLRP3的发现及其在冷吡啉相关周期性综合征和先天免疫中的作用

Putnam, Christopher D; Broderick, Lori; Hoffman, Hal M

BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation

BRP39 调节 NLRP3 炎症小体诱导的肝脏炎症中的中性粒细胞募集

Lin Kui ,Andrea D Kim ,Janset Onyuru ,Hal M Hoffman ,Ariel E Feldstein

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis

中性粒细胞中NLRP3的激活会诱发致命的自身炎症、肝脏炎症和纤维化。

Kaufmann, Benedikt; Leszczynska, Aleksandra; Reca, Agustina; Booshehri, Laela M; Onyuru, Janset; Tan, ZheHao; Wree, Alexander; Friess, Helmut; Hartmann, Daniel; Papouchado, Bettina; Broderick, Lori; Hoffman, Hal M; Croker, Ben A; Zhu, Yanfang Peipei; Feldstein, Ariel E

The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice

人乳寡糖3'-唾液酸乳糖可减轻小鼠的低度炎症和动脉粥样硬化发展。

Pessentheiner, Ariane R; Spann, Nathanael J; Autran, Chloe A; Oh, Tae Gyu; Grunddal, Kaare V; Coker, Joanna Kc; Painter, Chelsea D; Ramms, Bastian; Chiang, Austin Wt; Wang, Chen-Yi; Hsiao, Jason; Wang, Yiwen; Quach, Anthony; Booshehri, Laela M; Hammond, Alexandra; Tognaccini, Chiara; Latasiewicz, Joanna; Willemsen, Lisa; Zengler, Karsten; de Winther, Menno Pj; Hoffman, Hal M; Philpott, Martin; Cribbs, Adam P; Oppermann, Udo; Lewis, Nathan E; Witztum, Joseph L; Yu, Ruth; Atkins, Annette R; Downes, Michael; Evans, Ron M; Glass, Christopher K; Bode, Lars; Gordts, Philip Lsm