日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation

BRP39 调节 NLRP3 炎症小体诱导的肝脏炎症中的中性粒细胞募集

Lin Kui ,Andrea D Kim ,Janset Onyuru ,Hal M Hoffman ,Ariel E Feldstein

NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils

NET 形成是凋亡中性粒细胞中由 PAD4 控制的默认表观遗传程序

Yanfang Peipei Zhu, Mary Speir, ZheHao Tan, Jamie Casey Lee, Cameron J Nowell, Alyce A Chen, Hajera Amatullah, Ari J Salinger, Carolyn J Huang, Gio Wu, Weiqi Peng, Kasra Askari, Eric Griffis, Majid Ghassemian, Jennifer Santini, Motti Gerlic, William B Kiosses, Sergio D Catz, Hal M Hoffman, Kimberly

Long-term exposure to house dust mites accelerates lung cancer development in mice

长期接触屋尘螨会加速小鼠肺癌的发生发展。

Dongjie Wang ,Wen Li ,Natalie Albasha ,Lindsey Griffin ,Han Chang ,Lauren Amaya ,Sneha Ganguly ,Liping Zeng ,Bora Keum ,José M González-Navajas ,Matt Levin ,Zohreh AkhavanAghdam ,Helen Snyder ,David Schwartz ,Ailin Tao ,Laela M Boosherhri ,Hal M Hoffman ,Michael Rose ,Monica Valeria Estrada ,Nissi Varki ,Scott Herdman ,Maripat Corr ,Nicholas J G Webster ,Eyal Raz ,Samuel Bertin

Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation

NLRP3 与非氧化和 Ox-mtDNA 的差异结合介导 NLRP3 炎症小体激活

Angela Cabral #, Julia Elise Cabral #, Angelina Wang, Yiyang Zhang, Hailin Liang, Donya Nikbakht, Leslie Corona, Hal M Hoffman, Reginald McNulty

JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders

JT002,一种 NLRP3 炎症小体的小分子抑制剂,用于治疗自身炎症性疾病

Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M Santini, Rama Pranadinata, Casey D Johnson, Matthew D McGeough, Federico C Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M Hoffman, Ariel E Feldstein, Jeffrey A Stafford, James M Veal, 

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

氧化DNA片段通过mPTP和VDAC依赖性通道离开线粒体,激活NLRP3炎症小体和干扰素信号通路。

Hongxu Xian ,Kosuke Watari ,Elsa Sanchez-Lopez ,Joseph Offenberger ,Janset Onyuru ,Harini Sampath ,Wei Ying ,Hal M Hoffman ,Gerald S Shadel ,Michael Karin

NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH

NOD 样受体蛋白 3 的激活会引起自发性炎症和纤维化,类似于人类 NASH

David M Calcagno, Angela Chu, Susanne Gaul, Nika Taghdiri, Avinash Toomu, Aleksandra Leszczynska, Benedikt Kaufmann, Bettina Papouchado, Alexander Wree, Lukas Geisler, Hal M Hoffman, Ariel E Feldstein, Kevin R King

Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis

NLRP3 炎症小体的细胞特异性缺失表明髓系细胞是小鼠脂肪肝中肝脏炎症和纤维化的关键驱动因素

Benedikt Kaufmann, Lin Kui, Agustina Reca, Aleksandra Leszczynska, Andrea D Kim, Laela M Booshehri, Alexander Wree, Helmut Friess, Daniel Hartmann, Lori Broderick, Hal M Hoffman, Ariel E Feldstein

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis

中性粒细胞中NLRP3的激活会诱发致命的自身炎症、肝脏炎症和纤维化。

Benedikt Kaufmann ,Aleksandra Leszczynska ,Agustina Reca ,Laela M Booshehri ,Janset Onyuru ,ZheHao Tan ,Alexander Wree ,Helmut Friess ,Daniel Hartmann ,Bettina Papouchado ,Lori Broderick ,Hal M Hoffman ,Ben A Croker ,Yanfang Peipei Zhu # ,Ariel E Feldstein #

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

肝细胞焦亡和炎症小体颗粒的释放诱导星状细胞活化和肝纤维化

Susanne Gaul, Aleksandra Leszczynska, Fernando Alegre, Benedikt Kaufmann, Casey D Johnson, Leon A Adams, Alexander Wree, Georg Damm, Daniel Seehofer, Carolina J Calvente, Davide Povero, Tatiana Kisseleva, Akiko Eguchi, Matthew D McGeough, Hal M Hoffman, Pablo Pelegrin, Ulrich Laufs, Ariel E Feldstei