日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5

鉴定和优化首创的DDX1、LGP2和MDA5 RNA解旋酶抑制剂

Wang, Xiaowen; Wang, Feijun; Kong, Deyu; Uredi, Dilipkumar; Li, Fengling; Li, Feng; Rayadurgam, Jayachandra; Li, Hanxuan; Wolf, Esther; Chan, U Hang; Chau, Irene; Zeng, Hong; Perez, Julia Garcia; Wilson, Derek J; Bashore, Frances M; Wang, Xiaodong; Halabelian, Levon; Frankowski, Kevin J; Kireev, Dmitri; Axtman, Alison D

Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability

PRMT9基因双等位基因功能缺失变异会导致一种综合征型智力障碍。

Kröll-Hermi, Ariane; Stoetzel, Corinne; Etard, Christelle; Halabelian, Levon; Schaefer, Elise; Scheidecker, Sophie; Kahrizi, Kimia; Payman, Jamali; Geoffroy, Véronique; Prasad, Megana; Obringer, Cathy; Ruch, Laurie; Girard, Amandine; Zeng, Hong; Li, Fengling; Plassard, Damien; Keime, Céline; Mattioli, Francesca; Feger, Claire; Piton, Amélie; Fujita, Atsushi; Matsumoto, Naomichi; Castro, Matheus Augusto Araujo; Ae, Kim Chong; Ruaud, Lyse; Levy, Jonathan; Dozières, Blandine; Tabet, Anne-Claude; Wentzensen, Ingrid M; Santiago-Sim, Teresa; Yusupov, Roman; Tveten, Kristian; Smeland, Marie Falkenberg; Alkhunaizi, Ebba; Cowing, Gina; Li, Chumei; Wortmann, Saskia B; Feichtinger, René G; Mayr, Johannes A; Gonorazky, Herman; Jing, Gan; Wang, Xiaodong; Wang, Jia; Bierhals, Tatjana; Grinstein, Lev; Herget, Theresia; Ruiz, Anna; Gabau, Elisabeth; Kampmeier, Antje; Kassel, Olivier; Kuechler, Alma; Platzer, Konrad; Jamra, Rami Abou; Woerner, Audrey; Idleburg, Michaela; Kircher, Susanne Gerit; Laccone, Franco; Golob, Barbara; Peterlin, Borut; Čuturilo, Goran; Tasic, Velibor; Kolvenbach, Caroline M; Hildebrandt, Friedhelm; Ramos, Luiza L P; Kok, Fernando; Buck, Cecilia Barbosa; van de Laar, Ingrid M B H; de Man, Stella A; Taşdelen, Elifcan; Sezer, Abdullah; Büke, Afife; Yavuz, Zehra; Çomoğlu, Selim Selçuk; Costin, Carrie; Tran Mau Them, Frédéric; Lacaze, Elodie; Courtin, Thomas; Héron, Delphine; Keren, Boris; Whalen, Sandra; Roume, Joelle; Yang, Yanzhong; Hoffer, Mariëtte J V; van Haeringen, Arie; Najmabadi, Hossein; Arrowsmith, Cheryl H; Strähle, Uwe; Dollfus, Hélène; Muller, Jean

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1

在 CACHE Challenge #1 中,FRASE-bot 鉴定出了靶向 LRRK2 WD40 重复结构域的功能活性调节因子。

Akhila Mettu,Marta Glavatskikh,Xiaowen Wang,Antonio Jesús Lara Ordóñez,Fengling Li,Irene Chau,Suzanne Ackloo,Cheryl Arrowsmith,Albina Bolotokova,Pegah Ghiabi,Elisa Gibson,Levon Halabelian,Scott Houliston,Rachel J Harding,Ashley Hutchinson,Peter Loppnau,Sumera Perveen,Almagul Seitova,Hong Zeng,Matthieu Schapira,Jean-Marc Taymans,Dmitri Kireev

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Kimani Serah W, Noureldin Mahmoud, Wilson Brian, Hoffer Laurent, Green Stuart R, Szewczyk Magdalena M, González-Álvarez Héctor, Mohammed Mohammed, Chan Manuel, Krausser Chiara, Li Alice Shi Ming, Hajian Taraneh, Tucker Sarah, Joshi Dhananjay, Saraon Punit, Thériault Brigitte, Kim Ji Sup, Santhakumar Vijayaratnam, Loppnau Peter, Li Yanjun, Seitova Almagul, Dong Aiping, Kiyota Taira, Hammann Tobias, Gehrtz Paul, Patel Bhashant, Rathod Vaibhavi, Vala Anand, Rout Bhimsen, Jagodra Paras, Brown Peter J, Aman Ahmed, Ramnauth Jailall, Poda Gennady, Uehling David, Arrowsmith Cheryl H, Barsyte-Lovejoy Dalia, Marcellus Richard, Ackloo Suzanne, Mamai Ahmed, Al-Awar Rima, Halabelian Levon

Kinetic characterization of three human DExD/H-box RNA helicases

三种人类 DExD/H-box RNA 解旋酶的动力学表征

Fengling Li, U Hang Chan, Julia Garcia Perez, Hong Zeng, Irene Chau, Yanjun Li, Alma Seitova, Levon Halabelian

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity

DCAF1-PROTAC-WDR5三元复合物的晶体结构揭示了DCAF1的底物特异性

Mark F Mabanglo # ,Brian Wilson # ,Mahmoud Noureldin # ,Serah W Kimani ,Ahmed Mamai ,Chiara Krausser ,Héctor González-Álvarez ,Smriti Srivastava ,Mohammed Mohammed ,Laurent Hoffer ,Manuel Chan ,Jamie Avrumutsoae ,Alice Shi Ming Li ,Taraneh Hajian ,Sarah Tucker ,Stuart Green ,Magdalena Szewczyk ,Dalia Barsyte-Lovejoy ,Vijayaratnam Santhakumar ,Suzanne Ackloo ,Peter Loppnau ,Yanjun Li ,Almagul Seitova ,Taira Kiyota ,Jue George Wang ,Gilbert G Privé ,Douglas A Kuntz ,Bhashant Patel ,Vaibhavi Rathod ,Anand Vala ,Bhimsen Rout ,Ahmed Aman ,Gennady Poda ,David Uehling ,Jailall Ramnauth ,Levon Halabelian ,Richard Marcellus ,Rima Al-Awar ,Masoud Vedadi

Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing

PRMT9 的功能丧失突变通过 RNA 可变剪接失调导致突触发育异常

Lei Shen #, Xiaokuang Ma #, Yuanyuan Wang #, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Taiping Chen, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yang

ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation

ChemRAP 揭示通过 RNA 5' 磷酸甲基化调控特定 mRNA 翻译

Hélène Ipas #, Ellen B Gouws #, Nathan S Abell #, Po-Chin Chiou #, Sravan K Devanathan #, Solène Hervé #, Sidae Lee #, Marvin Mercado #, Calder Reinsborough #, Levon Halabelian, Cheryl H Arrowsmith, Blerta Xhemalçe

A ligand discovery toolbox for the WWE domain family of human E3 ligases

人类 E3 连接酶 WWE 结构域家族的配体发现工具箱

Lena Münzker #, Serah W Kimani #, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher

Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons

探究 CRL4DCAF12 与 MAGEA3 和 CCT5 双谷氨酸 C 末端降解产物的相互作用

Germanna Lima Righetto, Yanting Yin, David M Duda, Victoria Vu, Magdalena M Szewczyk, Hong Zeng, Yanjun Li, Peter Loppnau, Tony Mei, Yen-Yen Li, Alma Seitova, Aaron N Patrick, Jean-Francois Brazeau, Charu Chaudhry, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian