日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5

鉴定和优化首创的DDX1、LGP2和MDA5 RNA解旋酶抑制剂

Wang, Xiaowen; Wang, Feijun; Kong, Deyu; Uredi, Dilipkumar; Li, Fengling; Li, Feng; Rayadurgam, Jayachandra; Li, Hanxuan; Wolf, Esther; Chan, U Hang; Chau, Irene; Zeng, Hong; Perez, Julia Garcia; Wilson, Derek J; Bashore, Frances M; Wang, Xiaodong; Halabelian, Levon; Frankowski, Kevin J; Kireev, Dmitri; Axtman, Alison D

Enantioselective protein affinity selection mass spectrometry (E-ASMS)

对映选择性蛋白质亲和力选择质谱法(E-ASMS)

Wang, Xiaoyun; Sun, Jianxian; Ahmad, Shabbir; Yang, Diwen; Li, Fengling; Chan, U Hang; Zeng, Hong; Simoben, Conrad V; Green, Stuart R; Silva, Madhushika; Houliston, Scott; Dong, Aiping; Bolotokova, Albina; Gibson, Elisa; Kutera, Maria; Ghiabi, Pegah; Kondratov, Ivan; Matviyuk, Tetiana; Chuprina, Alexander; Mavridi, Danai; Lenz, Christopher; Joerger, Andreas C; Brown, Benjamin D; Heath, Richard B; Yue, Wyatt W; Robbie, Lucy K; Beyett, Tyler S; Müller, Susanne; Knapp, Stefan; Owen, Dafydd R; Harding, Rachel; Schapira, Matthieu; Brown, Peter J; Santhakumar, Vijayaratnam; Ackloo, Suzanne; Arrowsmith, Cheryl H; Edwards, Aled M; Peng, Hui; Halabelian, Levon

Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability

PRMT9基因双等位基因功能缺失变异会导致一种综合征型智力障碍。

Kröll-Hermi, Ariane; Stoetzel, Corinne; Etard, Christelle; Halabelian, Levon; Schaefer, Elise; Scheidecker, Sophie; Kahrizi, Kimia; Payman, Jamali; Geoffroy, Véronique; Prasad, Megana; Obringer, Cathy; Ruch, Laurie; Girard, Amandine; Zeng, Hong; Li, Fengling; Plassard, Damien; Keime, Céline; Mattioli, Francesca; Feger, Claire; Piton, Amélie; Fujita, Atsushi; Matsumoto, Naomichi; Castro, Matheus Augusto Araujo; Ae, Kim Chong; Ruaud, Lyse; Levy, Jonathan; Dozières, Blandine; Tabet, Anne-Claude; Wentzensen, Ingrid M; Santiago-Sim, Teresa; Yusupov, Roman; Tveten, Kristian; Smeland, Marie Falkenberg; Alkhunaizi, Ebba; Cowing, Gina; Li, Chumei; Wortmann, Saskia B; Feichtinger, René G; Mayr, Johannes A; Gonorazky, Herman; Jing, Gan; Wang, Xiaodong; Wang, Jia; Bierhals, Tatjana; Grinstein, Lev; Herget, Theresia; Ruiz, Anna; Gabau, Elisabeth; Kampmeier, Antje; Kassel, Olivier; Kuechler, Alma; Platzer, Konrad; Jamra, Rami Abou; Woerner, Audrey; Idleburg, Michaela; Kircher, Susanne Gerit; Laccone, Franco; Golob, Barbara; Peterlin, Borut; Čuturilo, Goran; Tasic, Velibor; Kolvenbach, Caroline M; Hildebrandt, Friedhelm; Ramos, Luiza L P; Kok, Fernando; Buck, Cecilia Barbosa; van de Laar, Ingrid M B H; de Man, Stella A; Taşdelen, Elifcan; Sezer, Abdullah; Büke, Afife; Yavuz, Zehra; Çomoğlu, Selim Selçuk; Costin, Carrie; Tran Mau Them, Frédéric; Lacaze, Elodie; Courtin, Thomas; Héron, Delphine; Keren, Boris; Whalen, Sandra; Roume, Joelle; Yang, Yanzhong; Hoffer, Mariëtte J V; van Haeringen, Arie; Najmabadi, Hossein; Arrowsmith, Cheryl H; Strähle, Uwe; Dollfus, Hélène; Muller, Jean

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

WD40重复序列蛋白的靶向配体结合能力评价

Ackloo, Suzanne; Li, Fengling; Szewczyk, Magda; Seitova, Almagul; Loppnau, Peter; Zeng, Hong; Xu, Jin; Ahmad, Shabbir; Arnautova, Yelena A; Baghaie, A J; Beldar, Serap; Bolotokova, Albina; Centrella, Paolo A; Chau, Irene; Clark, Matthew A; Cuozzo, John W; Dehghani-Tafti, Saba; Disch, Jeremy S; Dong, Aiping; Dumas, Antoine; Feng, Jianwen A; Ghiabi, Pegah; Gibson, Elisa; Gilmer, Justin; Goldman, Brian; Green, Stuart R; Guié, Marie-Aude; Guilinger, John P; Harms, Nathan; Herasymenko, Oleksandra; Houliston, Scott; Hutchinson, Ashley; Kearnes, Steven; Keefe, Anthony D; Kimani, Serah W; Kramer, Trevor; Kutera, Maria; Kwak, Haejin A; Lento, Cristina; Li, Yanjun; Liu, Jenny; Loup, Joachim; Machado, Raquel A C; Mulhern, Christopher J; Perveen, Sumera; Righetto, Germanna L; Riley, Patrick; Shrestha, Suman; Sigel, Eric A; Silva, Madhushika; Sintchak, Michael D; Slakman, Belinda L; Taylor, Rhys D; Thompson, James; Torng, Wen; Underkoffler, Carl; von Rechenberg, Moritz; Walsh, Ryan T; Watson, Ian; Wilson, Derek J; Wolf, Esther; Yadav, Manisha; Yazdi, Aliakbar K; Zhang, Junyi; Zhang, Ying; Santhakumar, Vijayaratnam; Edwards, Aled M; Barsyte-Lovejoy, Dalia; Schapira, Matthieu; Brown, Peter J; Halabelian, Levon; Arrowsmith, Cheryl H

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity

鉴定具有抗甲病毒活性的直接作用nsP2解旋酶抑制剂

Muthu Ramalingam, Bose; Sears, John D; Talbot, Kacey M; Su, Yuan-Wei Norman; Houliston, Scott; Hossain, Mohammed Anwar; Davis-Gilbert, Zachary W; Zhao, Chunqing; Oh, Hans J; Brown, Peter J; Sanders, Marcia K; Moorman, Stella R; Ojha, Durbadal; Burdick, Jane E; Law, Isabella; Morales, Noah L; Martinez, Sabian A; Loppnau, Peter; Garcia Perez, Julia; Drobish, Adam M; Morrison, Thomas E; Streblow, Zachary J; Streblow, Daniel N; Arrowsmith, Cheryl H; Vargason, Ava; Couñago, Rafael M; Halabelian, Levon; Arnold, Jamie J; Cameron, Craig E; Moorman, Nathaniel J; Heise, Mark T; Willson, Timothy M

Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders

利用开放式机器学习对脱氧核糖核酸编码文库进行筛选,加速小分子蛋白质结合剂的发现

Wellnitz, James; Ahmad, Shabbir; Bagale, Nabin; Cheng, Xuemin; Joseph, Jermiah; Zeng, Hong; Bolotokova, Albina; Dong, Aiping; Reza, Shaghayegh; Ghiabi, Pegah; Gibson, Elisa; Tu, Guiping; Li, Xianyang; Liu, Jian; Dou, Dengfeng; Li, Jin; Foley, Timothy L; Harris, Anthony R; Klug-McLeod, Jacquelyn L; Lee, Jisun; Lengyel-Zhand, Zsofia; Montgomery, Justin I; Sakata, Sylvie; Zhang, Jinzhi; Zhu, Hongyao; Owen, Dafydd R; Harding, Rachel J; Edwards, Aled M; Haibe-Kains, Benjamin; Halabelian, Levon; Tropsha, Alexander; Couñago, Rafael M

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Kimani Serah W, Noureldin Mahmoud, Wilson Brian, Hoffer Laurent, Green Stuart R, Szewczyk Magdalena M, González-Álvarez Héctor, Mohammed Mohammed, Chan Manuel, Krausser Chiara, Li Alice Shi Ming, Hajian Taraneh, Tucker Sarah, Joshi Dhananjay, Saraon Punit, Thériault Brigitte, Kim Ji Sup, Santhakumar Vijayaratnam, Loppnau Peter, Li Yanjun, Seitova Almagul, Dong Aiping, Kiyota Taira, Hammann Tobias, Gehrtz Paul, Patel Bhashant, Rathod Vaibhavi, Vala Anand, Rout Bhimsen, Jagodra Paras, Brown Peter J, Aman Ahmed, Ramnauth Jailall, Poda Gennady, Uehling David, Arrowsmith Cheryl H, Barsyte-Lovejoy Dalia, Marcellus Richard, Ackloo Suzanne, Mamai Ahmed, Al-Awar Rima, Halabelian Levon

Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

具有抗甲病毒活性的基孔肯雅病毒nsP2解旋酶对映选择性化学探针

Muthu Ramalingam, Bose; Oh, Hans J; Sears, John D; Chen, Chun-Hsing; Vala, Anand; Liu, Shubin; Talbot, Kacey M; Hossain, Mohammed Anwar; Brown, Peter J; Houliston, Scott; Garcia Perez, Julia; Li, Fengling; Amare, Meareg G; Halfmann, Peter; Smith, Jessica L; Hirsch, Alec J; Arrowsmith, Cheryl H; Halabelian, Levon; Vargason, Ava; Couñago, Rafael M; Arnold, Jamie J; Cameron, Craig E; Moorman, Nathaniel J; Heise, Mark T; Willson, Timothy M

Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit

高质量的DEL-ML命中加速了极具选择性的WDR5化学探针的发现

Hoffmann, Lasse; Lenz, Christopher; Farges, Frederic; Kimani, Serah W; Dopfer, Johannes; Keller, Sabrina; Schwalm, Martin Peter; Holzmann, Hanna; Kraemer, Andreas; Dong, Aiping; Li, Fengling; Chau, Irene; Halabelian, Levon; Gstaiger, Matthias; Müller, Susanne; Knapp, Stefan; Němec, Václav

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)

对映选择性蛋白质亲和力选择质谱法 (E-ASMS)

Wang, Xiaoyun; Sun, Jianxian; Ahmad, Shabbir; Yang, Diwen; Li, Fengling; Chan, U Hang; Zeng, Hong; Simoben, Conrad V; Green, Stuart R; Silva, Madhushika; Houliston, Scott; Dong, Aiping; Bolotokova, Albina; Gibson, Elisa; Kutera, Maria; Ghiabi, Pegah; Kondratov, Ivan; Matviyuk, Tetiana; Chuprina, Alexander; Mavridi, Danai; Lenz, Christopher; Joerger, Andreas C; Brown, Benjamin D; Heath, Richard B; Yue, Wyatt W; Robbie, Lucy K; Beyett, Tyler S; Müller, Susanne; Knapp, Stefan; Harding, Rachel; Schapira, Matthieu; Brown, Peter J; Santhakumar, Vijayaratnam; Ackloo, Suzanne; Arrowsmith, Cheryl H; Edwards, Aled M; Peng, Hui; Halabelian, Levon