日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults

一项 I/IIa 期研究旨在评估 ChAdOx1-MVA 载体疫苗(表达一种新型肝期疟疾双抗原 LS2)在未感染过疟疾的成年人中通过孢子攻击的安全性、免疫原性和有效性。

Silman, Daniel; Flaxman, Amy; Datoo, Mehreen; Edwards, Nick J; Ramos-Lopez, Fernando; Mitton, Celia; Mair, Catherine; Bellamy, Duncan; Bowyer, Georgina; Morter, Richard; Halbroth, Benedict; Venkatraman, Navin; Folegatti, Pedro M; Marshall, Julia; Poulton, Ian; Bajer, Amelia; Salman, Ahmed M; Berrie, Eleanor; Baum, Jake; Blagborough, Andrew M; Crocker, Wendy; Roberts, Rachel; Lawrie, Alison M; Spencer, Alexandra J; Gilbert, Sarah C; Ewer, Katie J; Hill, Adrian V S

Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria

表达恶性疟原虫LSA1和LSAP2融合抗原的病毒载体的临床前开发和评估,以评估其对肝期疟疾的疗效

Halbroth, Benedict R; Sebastian, Sarah; Salman, Ahmed M; Ulaszewska, Marta; Gola, Anita; Longley, Rhea J; Janse, Chris J; Khan, Shahid M; Hill, Adrian V S; Spencer, Alexandra J

Assessment of the Plasmodium falciparum Preerythrocytic Antigen UIS3 as a Potential Candidate for a Malaria Vaccine

评估恶性疟原虫红细胞前期抗原UIS3作为疟疾疫苗潜在候选抗原的价值

Longley, Rhea J; Halbroth, Benedict R; Salman, Ahmed M; Ewer, Katie J; Hodgson, Susanne H; Janse, Chris J; Khan, Shahid M; Hill, Adrian V S; Spencer, Alexandra J

Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice

在多种小鼠品系中鉴定针对恶性疟原虫抗原PfUIS3、PfLSA1和PfLSAP2的免疫优势反应

Longley, Rhea J; Halbroth, Benedict R; Ewer, Katie J; Hill, Adrian V S; Spencer, Alexandra J

Superior in vitro stimulation of human CD8+ T-cells by whole virus versus split virus influenza vaccines

全病毒流感疫苗比裂解病毒流感疫苗更能体外刺激人CD8+ T细胞

Halbroth, Benedict R; Heil, Alexander; Distler, Eva; Dass, Martin; Wagner, Eva M; Plachter, Bodo; Probst, Hans Christian; Strand, Dennis; Hartwig, Udo F; Karner, Anita; Aichinger, Gerald; Kistner, Otfried; Landfester, Katharina; Herr, Wolfgang