日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice

特定的醌还原酶 2 抑制剂可减轻小鼠的代谢负担并逆转阿尔茨海默病表型

Nathaniel L Gould, Gila R Scherer, Silvia Carvalho, Khriesto Shurrush, Haneen Kayyal, Efrat Edry, Alina Elkobi, Orit David, Maria Foqara, Darshit Thakar, Tommaso Pavesi, Vijendra Sharma, Matthew Walker, Matthew Maitland, Orly Dym, Shira Albeck, Yoav Peleg, Nicolas Germain, Ilana Babaev, Haleli Shari

Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments

不同化学环境中社区相关 MRSA 中 mecA 的普遍选择

Olga Snitser, Dor Russ, Laura K Stone, Kathy K Wang, Haleli Sharir, Noga Kozer, Galit Cohen, Haim M Barr, Roy Kishony

A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors

基于药物伴侣的高通量筛选试验,用于发现孤儿受体的化学探针

Camilo J Morfa, Daniel Bassoni, Andras Szabo, Danielle McAnally, Haleli Sharir, Becky L Hood, Stefan Vasile, Tom Wehrman, Jane Lamerdin, Layton H Smith

Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

GPR55拮抗剂的设计、合成和分析:哌啶取代的1,3,4-恶二唑-2-酮

Meza-Aviña, Maria Elena; Lingerfelt, Mary A; Console-Bram, Linda M; Gamage, Thomas F; Sharir, Haleli; Gettys, Kristen E; Hurst, Dow P; Kotsikorou, Evangelia; Shore, Derek M; Caron, Marc G; Rao, Narasinga; Barak, Larry S; Abood, Mary E; Reggio, Patricia H; Croatt, Mitchell P

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

CB2 选择性大麻素受体配体:1,8-萘啶-2(1H)-酮-3-甲酰胺的合成、药理评价及分子建模研究

Valentina Lucchesi, Dow P Hurst, Derek M Shore, Simone Bertini, Brandie M Ehrmann, Marco Allarà, Lyle Lawrence, Alessia Ligresti, Filippo Minutolo, Giuseppe Saccomanni, Haleli Sharir, Marco Macchia, Vincenzo Di Marzo, Mary E Abood, Patricia H Reggio, Clementina Manera

The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55

内源性大麻素 anandamide 和 virodhamine 调节候选大麻素受体 GPR55 的活性

Haleli Sharir, Linda Console-Bram, Christina Mundy, Steven N Popoff, Ankur Kapur, Mary E Abood

Pharmacological characterization of GPR55, a putative cannabinoid receptor

GPR55(一种假定的内源性大麻素受体)的药理学特征

Sharir, Haleli; Abood, Mary E

Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity

帕莫酸靶向孤儿受体 GPR35:一种具有抗伤害活性的细胞外信号调节激酶和 β-arrestin2 的强效激活剂

Pingwei Zhao, Haleli Sharir, Ankur Kapur, Alan Cowan, Ellen B Geller, Martin W Adler, Herbert H Seltzman, Patricia H Reggio, Susanne Heynen-Genel, Michelle Sauer, Thomas D Y Chung, Yushi Bai, Wei Chen, Marc G Caron, Larry S Barak, Mary E Abood

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands

孤儿受体 GPR55 对大麻素配体的非典型反应

Ankur Kapur, Pingwei Zhao, Haleli Sharir, Yushi Bai, Marc G Caron, Larry S Barak, Mary E Abood