日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

变构 PI3Kα 抑制剂可克服由继发性 PIK3CA 突变介导的对正构抑制剂的靶向耐药性

Andreas Varkaris #, Ferran Fece de la Cruz #, Elizabeth E Martin #, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi

FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma

FGFR 抑制阻断 NF-ĸB 依赖性葡萄糖代谢并导致胆管癌代谢脆弱性

Yuanli Zhen, Kai Liu, Lei Shi, Simran Shah, Qin Xu, Haley Ellis, Eranga R Balasooriya, Johannes Kreuzer, Robert Morris, Albert S Baldwin, Dejan Juric, Wilhelm Haas, Nabeel Bardeesy

The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations

不可逆 FGFR 抑制剂 KIN-3248 可克服 FGFR2 激酶结构域突变

Eranga R Balasooriya #, Qibiao Wu #, Haley Ellis, Yuanli Zhen, Bryanna L Norden, Ryan B Corcoran, Adithi Mohan, Eric Martin, Aleksandra Franovic, John Tyhonas, Matthew Lardy, Kathryn B Grandinetti, Robert Pelham, Liliana Soroceanu, Vanessa S Silveira, Nabeel Bardeesy

Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma

FGFR2 变异胆管癌对 FGFR 抑制剂的临床耐药机制概况

Qibiao Wu, Haley Ellis, Giulia Siravegna, Alexa G Michel, Bryanna L Norden, Ferran Fece de la Cruz, Eranga Roshan Balasooriya, Yuanli Zhen, Vanessa S Silveira, Jianwe Che, Ryan B Corcoran, Nabeel Bardeesy

Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets

通过联合使用破骨细胞阻断和粒细胞亚群消耗,可以有效治疗已确诊的骨转移瘤

Aude-Hélène Capietto #, Seunghyun Lee #, David Clever, Emily Eul, Haley Ellis, Cynthia X Ma, Roberta Faccio

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

PTEN 的逐渐丧失导致临床对 PI(3)Kα 抑制剂产生耐药性

Dejan Juric, Pau Castel, Malachi Griffith, Obi L Griffith, Helen H Won, Haley Ellis, Saya H Ebbesen, Benjamin J Ainscough, Avinash Ramu, Gopa Iyer, Ronak H Shah, Tiffany Huynh, Mari Mino-Kenudson, Dennis Sgroi, Steven Isakoff, Ashraf Thabet, Leila Elamine, David B Solit, Scott W Lowe, Cornelia Quadt