日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Predictors of response and rational combinations for the novel MCL-1 inhibitor MIK665 in acute myeloid leukemia

预测新型 MCL-1 抑制剂 MIK665 在急性髓系白血病中的疗效及合理联合用药方案

Saad, Joseph; Newman, Rhiannon; Khabusheva, Elmira; Aakko, Sofia; Durand, Eric; Tambe, Mahesh; Kuusanmäki, Heikki; Parsons, Alun; Miettinen, Juho J; Javarappa, Komal Kumar; Olgac, Ezgi June; Ikonen, Nemo; Kontro, Mika; Porkka, Kimmo; Maacke, Heiko; Woo, Janghee; Halilovic, Ensar; Heckman, Caroline A

BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics

BH3谱分析作为BH3模拟物活性的药效学生物标志物

Pan, Rongqing Aaron; Wang, Youzhen; Qiu, Shumei; Villalobos-Ortiz, Mariana; Ryan, Jeremy; Morris, Erick; Halilovic, Ensar; Letai, Anthony

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.

BAX 基因的获得性突变可使急性髓系白血病对 BH3 模拟疗法产生耐药性

Moujalled Donia M, Brown Fiona C, Chua Chong Chyn, Dengler Michael A, Pomilio Giovanna, Anstee Natasha S, Litalien Veronique, Thompson Ella, Morley Thomas, MacRaild Sarah, Tiong Ing S, Morris Rhiannon, Dun Karen, Zordan Adrian, Shah Jaynish, Banquet Sebastien, Halilovic Ensar, Morris Erick, Herold Marco J, Lessene Guillaume, Adams Jerry M, Huang David C S, Roberts Andrew W, Blombery Piers, Wei Andrew H

Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia

Siremadlin (HDM201) 治疗晚期野生型 TP53 实体瘤和急性白血病患者的首次人体 I 期研究结果

Stein, Eytan M; DeAngelo, Daniel J; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma

在多发性骨髓瘤中,S63845 和维奈托克联合用药同时抑制 MCL-1 和 BCL-2 的临床前评估

Algarín, Esperanza M; Díaz-Tejedor, Andrea; Mogollón, Pedro; Hernández-García, Susana; Corchete, Luis A; San-Segundo, Laura; Martín-Sánchez, Montserrat; González-Méndez, Lorena; Schoumacher, Marie; Banquet, Sebastien; Kraus-Berthier, Laurence; Kloos, Ioana; Derreal, Alix; Halilovic, Ensar; Maacke, Heiko; Gutiérrez, Norma C; Mateos, María-Victoria; Paíno, Teresa; Garayoa, Mercedes; Ocio, Enrique M

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

代表黑色素瘤异质性的综合性患者来源异种移植模型库

Krepler, Clemens; Sproesser, Katrin; Brafford, Patricia; Beqiri, Marilda; Garman, Bradley; Xiao, Min; Shannan, Batool; Watters, Andrea; Perego, Michela; Zhang, Gao; Vultur, Adina; Yin, Xiangfan; Liu, Qin; Anastopoulos, Ioannis N; Wubbenhorst, Bradley; Wilson, Melissa A; Xu, Wei; Karakousis, Giorgos; Feldman, Michael; Xu, Xiaowei; Amaravadi, Ravi; Gangadhar, Tara C; Elder, David E; Haydu, Lauren E; Wargo, Jennifer A; Davies, Michael A; Lu, Yiling; Mills, Gordon B; Frederick, Dennie T; Barzily-Rokni, Michal; Flaherty, Keith T; Hoon, Dave S; Guarino, Michael; Bennett, Joseph J; Ryan, Randall W; Petrelli, Nicholas J; Shields, Carol L; Terai, Mizue; Sato, Takami; Aplin, Andrew E; Roesch, Alexander; Darr, David; Angus, Steve; Kumar, Rakesh; Halilovic, Ensar; Caponigro, Giordano; Jeay, Sebastien; Wuerthner, Jens; Walter, Annette; Ocker, Matthias; Boxer, Matthew B; Schuchter, Lynn; Nathanson, Katherine L; Herlyn, Meenhard

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

异种移植公共数据库促进了小鼠的发现和随机II期样试验

Townsend, Elizabeth C; Murakami, Mark A; Christodoulou, Alexandra; Christie, Amanda L; Köster, Johannes; DeSouza, Tiffany A; Morgan, Elizabeth A; Kallgren, Scott P; Liu, Huiyun; Wu, Shuo-Chieh; Plana, Olivia; Montero, Joan; Stevenson, Kristen E; Rao, Prakash; Vadhi, Raga; Andreeff, Michael; Armand, Philippe; Ballen, Karen K; Barzaghi-Rinaudo, Patrizia; Cahill, Sarah; Clark, Rachael A; Cooke, Vesselina G; Davids, Matthew S; DeAngelo, Daniel J; Dorfman, David M; Eaton, Hilary; Ebert, Benjamin L; Etchin, Julia; Firestone, Brant; Fisher, David C; Freedman, Arnold S; Galinsky, Ilene A; Gao, Hui; Garcia, Jacqueline S; Garnache-Ottou, Francine; Graubert, Timothy A; Gutierrez, Alejandro; Halilovic, Ensar; Harris, Marian H; Herbert, Zachary T; Horwitz, Steven M; Inghirami, Giorgio; Intlekofer, Andrew M; Ito, Moriko; Izraeli, Shai; Jacobsen, Eric D; Jacobson, Caron A; Jeay, Sébastien; Jeremias, Irmela; Kelliher, Michelle A; Koch, Raphael; Konopleva, Marina; Kopp, Nadja; Kornblau, Steven M; Kung, Andrew L; Kupper, Thomas S; LeBoeuf, Nicole R; LaCasce, Ann S; Lees, Emma; Li, Loretta S; Look, A Thomas; Murakami, Masato; Muschen, Markus; Neuberg, Donna; Ng, Samuel Y; Odejide, Oreofe O; Orkin, Stuart H; Paquette, Rachel R; Place, Andrew E; Roderick, Justine E; Ryan, Jeremy A; Sallan, Stephen E; Shoji, Brent; Silverman, Lewis B; Soiffer, Robert J; Steensma, David P; Stegmaier, Kimberly; Stone, Richard M; Tamburini, Jerome; Thorner, Aaron R; van Hummelen, Paul; Wadleigh, Martha; Wiesmann, Marion; Weng, Andrew P; Wuerthner, Jens U; Williams, David A; Wollison, Bruce M; Lane, Andrew A; Letai, Anthony; Bertagnolli, Monica M; Ritz, Jerome; Brown, Myles; Long, Henry; Aster, Jon C; Shipp, Margaret A; Griffin, James D; Weinstock, David M

Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097

更正:一组独特的 p53 靶基因可预测对选择性 p53-HDM2 抑制剂 NVP-CGM097 的反应。

Jeay, Sébastien; Gaulis, Swann; Ferretti, Stéphane; Bitter, Hans; Ito, Moriko; Valat, Thérèse; Murakami, Masato; Ruetz, Stephan; Guthy, Daniel A; Rynn, Caroline; Jensen, Michael R; Wiesmann, Marion; Kallen, Joerg; Furet, Pascal; Gessier, François; Holzer, Philipp; Masuya, Keiichi; Würthner, Jens; Halilovic, Ensar; Hofmann, Francesco; Sellers, William R; Graus Porta, Diana

A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097

一组独特的p53靶基因预测了对选择性p53-HDM2抑制剂NVP-CGM097的反应

Jeay, Sébastien; Gaulis, Swann; Ferretti, Stéphane; Bitter, Hans; Ito, Moriko; Valat, Thérèse; Murakami, Masato; Ruetz, Stephan; Guthy, Daniel A; Rynn, Caroline; Jensen, Michael R; Wiesmann, Marion; Kallen, Joerg; Furet, Pascal; Gessier, François; Holzer, Philipp; Masuya, Keiichi; Würthner, Jens; Halilovic, Ensar; Hofmann, Francesco; Sellers, William R; Graus Porta, Diana

Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas

RAF抑制剂对促有丝分裂信号的深度反馈抑制的解除,会减弱其在BRAFV600E黑色素瘤中的活性。

Lito, Piro; Pratilas, Christine A; Joseph, Eric W; Tadi, Madhavi; Halilovic, Ensar; Zubrowski, Matthew; Huang, Alan; Wong, Wai Lin; Callahan, Margaret K; Merghoub, Taha; Wolchok, Jedd D; de Stanchina, Elisa; Chandarlapaty, Sarat; Poulikakos, Poulikos I; Fagin, James A; Rosen, Neal