日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource.

利用人类 iPSC 模拟具有高低多基因风险的常见阿尔茨海默病:大规模研究资源

Maguire Emily, Winston Jincy, Ellwood Sarah H, O'Donoghue Rachel, Shaw Bethany, Morales Atahualpa Castillo, Keat Samuel, Evans Alexandra, Marshall Rachel, Luckcuck Lauren, Brown Laura, Salis Elisa, Leonenko Ganna, Denning Nicola, Allen Nicholas D, Escott-Price Valentina, Webber Caleb, Taylor Philip R, Sims Rebecca, Cowley Sally A, Williams Julie, Carpanini Sarah M, Hall-Roberts Hazel

Human iPSC-derived glia models for the study of neuroinflammation

用于研究神经炎症的人类iPSC衍生胶质细胞模型

Stöberl, Nina; Maguire, Emily; Salis, Elisa; Shaw, Bethany; Hall-Roberts, Hazel

Mutant huntingtin confers cell-autonomous phenotypes on Huntington's disease iPSC-derived microglia

突变型亨廷顿蛋白赋予亨廷顿病诱导多能干细胞衍生的小胶质细胞细胞自主表型

Nina Stöberl ,Jasmine Donaldson ,Caroline S Binda ,Branduff McAllister ,Hazel Hall-Roberts ,Lesley Jones ,Thomas H Massey ,Nicholas D Allen

Assaying Microglia Functions In Vitro

体外检测小胶质细胞功能

Maguire, Emily; Connor-Robson, Natalie; Shaw, Bethany; O'Donoghue, Rachel; Stöberl, Nina; Hall-Roberts, Hazel

PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

PLCγ2 调节 TREM2 信号传导和整合素介导的人类 iPSC 衍生巨噬细胞的粘附和迁移

Juliane Obst, Hazel L Hall-Roberts, Thomas B Smith, Mira Kreuzer, Lorenza Magno, Elena Di Daniel, John B Davis, Emma Mead

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

TREM2 阿尔茨海默病变体 R47H 会导致与基因敲除类似的转录失调,但在人类 iPSC 衍生的巨噬细胞中仅表现出轻微的功能表型。

Hazel Hall-Roberts ,Devika Agarwal ,Juliane Obst ,Thomas B Smith ,Jimena Monzón-Sandoval ,Elena Di Daniel ,Caleb Webber ,William S James ,Emma Mead ,John B Davis ,Sally A Cowley