日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision medicine for sodium channelopathy-related autism and epilepsy

针对钠通道病相关自闭症和癫痫的精准医疗

Robinson, Morgan; Wettschurack, Kyle; Halurkar, Manasi S; Chen, Xiaoling; Zhang, Zaiyang; Zhang, Jingliang; Yang, Yang

The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes.

广泛使用的 Ucp1-Cre 转基因可引起复杂的发育和代谢表型

Halurkar Manasi Suchit, Inoue Oto, Singh Archana, Mukherjee Rajib, Ginugu Meghana, Ahn Christopher, Bonatto Paese Christian Louis, Duszynski Molly, Brugmann Samantha A, Lim Hee-Woong, Sanchez-Gurmaches Joan

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

癫痫相关的SCN2A-L1342P突变驱动人类皮质类器官网络过度兴奋和广泛的转录组变化

Olivero-Acosta, Maria I; Robinson, Morgan; Que, Zhefu; Zhang, Zaiyang; Harlow, Hope Elizabeth; Shankar, Vinayak; Hong, Seoyong; Wang, Muhan; Otterbacher, Conrad M; Kadono, Hina; Halurkar, Manasi; Kothandaraman, Harish; Lanman, Nadia; Nguyen, Trang; Wettschurack, Kyle; Zirkle, Benjamin; Yunis, Layan; Cui, Ningren; Chen, Xiaoling; Zhang, Jingliang; Wu, Jiaxiang; Skarnes, William C; Yuan, Chongli; Guo, Feng; Yang, Yang

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice.

基因疗法可缓解 DBA/2J 小鼠中与 Scn2a 缺陷相关的失神性癫痫

Zhang Zaiyang, Zhang Jingliang, Chen Xiaoling, Deming Brody A, Kant Shivam, Mandal Purba, Kothandaraman Harish, SanMiguel Phillip J, Halurkar Manasi S, Abeyaratna Akila D, Robinson Morgan J, Zhao Yuanrui, Vitko Yuliia, Gaykema Ronald P, Yuan Chongli, Lanman Nadia A, Tegtmeyer Matthew T, Wang Dan, Gao Guangping, Shi Riyi, Perez-Reyes Edward, Yang Yang

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency.

恢复兴奋/抑制平衡可提高神经元信噪比,并挽救自闭症相关 Scn2a 缺陷引起的社交缺陷

Zhang Jingliang, Eaton Muriel, Chen Xiaoling, Zhao Yuanrui, Kant Shivam, Deming Brody A, Harish Kothandaraman, Nguyen Huynhvi P, Shu Yue, Lai Shirong, Wu Jiaxiang, Que Zhefu, Wettschurack Kyle W, Zhang Zaiyang, Xiao Tiange, Halurkar Manasi S, Olivero-Acosta Maria I, Yoo Ye-Eun, Lanman Nadia A, Koss Wendy A, Skarnes William C, Yang Yang

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.

与自闭症相关的 SCN2A 缺陷会破坏人类大脑组装体中的皮质纹状体回路

Chen Xiaoling, Zhang Jingliang, Wu Jiaxiang, Robinson Morgan J, Kothandaraman Harish, Yoo Ye-Eun, Dopeso-Reyes Iria M Gonzalez, Buffenoir Thomas D, Halurkar Manasi S, Zhang Zaiyang, Wang Muhan, Creager Erin N, Zhao Yuanrui, Olivero-Acosta Maria I, Wettschurack Kyle W, Que Zhefu, Yuan Chongli, Schaser Allison J, Lanman Nadia A, Rochet Jean-Christophe, Skarnes William C, Kremer Eric J, Yang Yang

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.

人类 iPSC 衍生的小胶质细胞能够感知并抑制携带癫痫相关 SCN2A-L1342P 突变的皮层神经元的过度兴奋

Que Zhefu, Olivero-Acosta Maria I, Robinson Morgan, Chen Ian, Zhang Jingliang, Wettschurack Kyle, Wu Jiaxiang, Xiao Tiange, Otterbacher C Max, Shankar Vinayak, Harlow Hope, Hong Seoyong, Zirkle Benjamin, Wang Muhan, Cui Ningren, Mandal Purba, Chen Xiaoling, Deming Brody, Halurkar Manasi, Zhao Yuanrui, Rochet Jean-Christophe, Xu Ranjie, Brewster Amy L, Wu Long-Jun, Yuan Chongli, Skarnes William C, Yang Yang

Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia

单细胞转录组学鉴定脂肪组织 CD271+ 祖细胞,以增强肢体缺血中的血管生成

Oto Inoue, Chiaki Goten, Daiki Hashimuko, Kosei Yamaguchi, Yusuke Takeda, Ayano Nomura, Hiroshi Ootsuji, Shinichiro Takashima, Kenji Iino, Hirofumi Takemura, Manasi Halurkar, Hee-Woong Lim, Vivian Hwa, Joan Sanchez-Gurmaches, Soichiro Usui, Masayuki Takamura

The widely used Ucp1-CreEvdr transgene elicits complex developmental and metabolic phenotypes

广泛使用的 Ucp1-CreEvdr 转基因引发复杂的发育和代谢表型

Manasi Suchit Halurkar, Oto Inoue, Rajib Mukherjee, Christian Louis Bonatto Paese, Molly Duszynski, Samantha A Brugmann, Hee-Woong Lim, Joan Sanchez-Gurmaches

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

人类 iPSC 衍生的小胶质细胞感知并抑制携带癫痫相关 SCN2A-L1342P 突变的皮质神经元的过度兴奋

Zhefu Que, Maria I Olivero-Acosta, Ian Chen, Jingliang Zhang, Kyle Wettschurack, Jiaxiang Wu, Tiange Xiao, C Max Otterbacher, Muhan Wang, Hope Harlow, Ningren Cui, Xiaoling Chen, Brody Deming, Manasi Halurkar, Yuanrui Zhao, Jean-Christophe Rochet, Ranjie Xu, Amy L Brewster, Long-Jun Wu, Chongli Yuan