日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision medicine for sodium channelopathy-related autism and epilepsy

针对钠通道病相关自闭症和癫痫的精准医疗

Robinson, Morgan; Wettschurack, Kyle; Halurkar, Manasi S; Chen, Xiaoling; Zhang, Zaiyang; Zhang, Jingliang; Yang, Yang

The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes.

广泛使用的 Ucp1-Cre 转基因可引起复杂的发育和代谢表型

Halurkar Manasi Suchit, Inoue Oto, Singh Archana, Mukherjee Rajib, Ginugu Meghana, Ahn Christopher, Bonatto Paese Christian Louis, Duszynski Molly, Brugmann Samantha A, Lim Hee-Woong, Sanchez-Gurmaches Joan

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a -deficient mice

单核转录组学揭示了Scn2a缺陷小鼠前额叶皮层中受损的通路

Yoo, Ye-Eun; Mandal, Purba; Tang, Zhengkuan; Zhang, Zaiyang; Zhang, Jingliang; Chen, Xiaoling; Robinson, Morgan; Eaton, Muriel; Deming, Brody; Halurkar, Manasi; Kothandaraman, Harish; Dabin, Luke C; Jiang, Boyu; Gao, Hongyu; Yuan, Chongli; Lanman, Nadia; Liu, Yunlong; Kim, Jungsu; Baloni, Priyanka; Yang, Yang

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

癫痫相关的SCN2A-L1342P突变驱动人类皮质类器官网络过度兴奋和广泛的转录组变化

Olivero-Acosta, Maria I; Robinson, Morgan; Que, Zhefu; Zhang, Zaiyang; Harlow, Hope Elizabeth; Shankar, Vinayak; Hong, Seoyong; Wang, Muhan; Otterbacher, Conrad M; Kadono, Hina; Halurkar, Manasi; Kothandaraman, Harish; Lanman, Nadia; Nguyen, Trang; Wettschurack, Kyle; Zirkle, Benjamin; Yunis, Layan; Cui, Ningren; Chen, Xiaoling; Zhang, Jingliang; Wu, Jiaxiang; Skarnes, William C; Yuan, Chongli; Guo, Feng; Yang, Yang

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice.

基因疗法可缓解 DBA/2J 小鼠中与 Scn2a 缺陷相关的失神性癫痫

Zhang Zaiyang, Zhang Jingliang, Chen Xiaoling, Deming Brody A, Kant Shivam, Mandal Purba, Kothandaraman Harish, SanMiguel Phillip J, Halurkar Manasi S, Abeyaratna Akila D, Robinson Morgan J, Zhao Yuanrui, Vitko Yuliia, Gaykema Ronald P, Yuan Chongli, Lanman Nadia A, Tegtmeyer Matthew T, Wang Dan, Gao Guangping, Shi Riyi, Perez-Reyes Edward, Yang Yang

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency.

恢复兴奋/抑制平衡可提高神经元信噪比,并挽救自闭症相关 Scn2a 缺陷引起的社交缺陷

Zhang Jingliang, Eaton Muriel, Chen Xiaoling, Zhao Yuanrui, Kant Shivam, Deming Brody A, Harish Kothandaraman, Nguyen Huynhvi P, Shu Yue, Lai Shirong, Wu Jiaxiang, Que Zhefu, Wettschurack Kyle W, Zhang Zaiyang, Xiao Tiange, Halurkar Manasi S, Olivero-Acosta Maria I, Yoo Ye-Eun, Lanman Nadia A, Koss Wendy A, Skarnes William C, Yang Yang

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.

与自闭症相关的 SCN2A 缺陷会破坏人类大脑组装体中的皮质纹状体回路

Chen Xiaoling, Zhang Jingliang, Wu Jiaxiang, Robinson Morgan J, Kothandaraman Harish, Yoo Ye-Eun, Dopeso-Reyes Iria M Gonzalez, Buffenoir Thomas D, Halurkar Manasi S, Zhang Zaiyang, Wang Muhan, Creager Erin N, Zhao Yuanrui, Olivero-Acosta Maria I, Wettschurack Kyle W, Que Zhefu, Yuan Chongli, Schaser Allison J, Lanman Nadia A, Rochet Jean-Christophe, Skarnes William C, Kremer Eric J, Yang Yang

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.

人类 iPSC 衍生的小胶质细胞能够感知并抑制携带癫痫相关 SCN2A-L1342P 突变的皮层神经元的过度兴奋

Que Zhefu, Olivero-Acosta Maria I, Robinson Morgan, Chen Ian, Zhang Jingliang, Wettschurack Kyle, Wu Jiaxiang, Xiao Tiange, Otterbacher C Max, Shankar Vinayak, Harlow Hope, Hong Seoyong, Zirkle Benjamin, Wang Muhan, Cui Ningren, Mandal Purba, Chen Xiaoling, Deming Brody, Halurkar Manasi, Zhao Yuanrui, Rochet Jean-Christophe, Xu Ranjie, Brewster Amy L, Wu Long-Jun, Yuan Chongli, Skarnes William C, Yang Yang

EPC-EXs improve astrocyte survival and oxidative stress through different uptaking pathways in diabetic hypoxia condition

EPC-EXs通过不同的摄取途径改善糖尿病缺氧条件下星形胶质细胞的存活率和氧化应激。

Halurkar, Manasi Suchit; Wang, Jinju; Chen, Shuzhen; Bihl, Ji Chen