日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization

苯并环庚烯及其四环类似物作为秋水仙碱位点抑制剂抑制微管蛋白聚合

VanNatta, Jennifer M; Carlson, Graham J; Niu, Haichan; Bai, Ruoli; Wanniarachchi, Hashini I; Schuetze, Regan; Trawick, Mary Lynn; Hamel, Ernest; Mason, Ralph P; Pinney, Kevin G

Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization

利用源自二氢萘、苯并环庚烯和吲哚类微管蛋白聚合抑制剂的生物还原活化前药缀合物靶向肿瘤相关缺氧

Shi, Zhe; Guddneppanavar, Rajsekhar; Winn, Blake A; MacDonough, Matthew T; George, Clinton S; Wang, Yifan; Zimmer, Mark; Gerberich, Jeni; Winters, Alex; Lin, Elisa; Maguire, Casey J; Ford, Jacob; Hamel, Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G

Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach.

利用芳环反转和连接方法微波辅助合成微管蛋白组装抑制剂作为抗癌剂

Masci Domiziana, Puxeddu Michela, Colla Claudia, Coluccia Antonio, Santelli Martina, Sciò Pietro, Mariotto Elena, Viola Giampietro, Hamel Ernest, Lerose Rosa, Mazzoccoli Carmela, Silvestri Romano, La Regina Giuseppe

Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents

OXi8006 的 2-苯基吲哚类似物作为秋水仙碱位点抑制剂抑制微管蛋白聚合和血管破坏剂的设计、合成和生物学评价

Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel, Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G

Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers

具有独特双机制微管蛋白结合有效载荷的药物连接子结构,通过可切割和不可切割连接子连接

Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G

Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents

康布瑞他汀A-4的硼酸生物等排体的合成及其作为抗癌药物的构效关系研究

Kong, Yali; Edler, Michael C; Hamel, Ernest; Britton-Jenkins, Asa R; Gillan, Omar; Mooberry, Susan L; Mu, David; Brown, Milton L

Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

吡咯并[3',4':3,4]环庚并[1,2-d][1,2]噁唑类化合物被鉴定为治疗淋巴瘤的潜在新候选药物

Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Gualtieri, Gianmarco; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Manfreda, Lorenzo; Bai, Ruoli; Montalbano, Alessandra; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Viola, Giampietro; Barraja, Paola

Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues

基于结构的含氧杂环丁烷吲哚类似物的设计、合成及生物学评价

Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai, Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site

简单的单环嘧啶类似物作为微管靶向剂,可与秋水仙碱位点结合

Choudhary, Shruti; Kaku, Krishna; Robles, Andrew J; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

5,6,7,8-四氢苯并[4,5]噻吩并[2,3-d]嘧啶类化合物作为微管靶向剂的设计、合成及生物学评价

Islam, Farhana; Doshi, Arpit; Robles, Andrew J; Quadery, Tasdique M; Zhang, Xin; Zhou, Xilin; Hamel, Ernest; Mooberry, Susan L; Gangjee, Aleem