Hamilton Alex G相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

利用条形码mRNA进行高通量体内筛选，鉴定出具有肝外趋向性的脂质纳米颗粒，用于原位免疫工程

期刊:Advanced Materials

影响因子:26.8

doi:10.1002/adma.202514370

Hamilton, Alex G; Thatte, Ajay S; Xu, Junchao; Luo, Zhangyi; Safford, Hannah C; Swingle, Kelsey L; Muscat-Rivera, Jenna; Kegel, Michael; Han, Xuexiang; Joseph, Ryann A; Murray, Amanda M; Geisler, Hannah C; Whitaker, Ricardo C; Xue, Lulu; Spektor, Roman; Melamed, Jilian R; Weissman, Drew; Mitchell, Michael J

免疫/内分泌

发表日期：2026

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Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia.

胎盘趋向性 VEGF mRNA 脂质纳米颗粒可改善小鼠先兆子痫

影响因子:48.5

doi:10.1038/s41586-024-08291-2

Swingle Kelsey L, Hamilton Alex G, Safford Hannah C, Geisler Hannah C, Thatte Ajay S, Palanki Rohan, Murray Amanda M, Han Emily L, Mukalel Alvin J, Han Xuexiang, Joseph Ryann A, Ghalsasi Aditi A, Alameh Mohamad-Gabriel, Weissman Drew, Mitchell Michael J

发表日期：2025

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Circular RNA lipid nanoparticle vaccine against SARS-CoV-2

针对SARS-CoV-2的环状RNA脂质纳米颗粒疫苗

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2505718122

Swingle, Kelsey L; Hamilton, Alex G; Han, Xuexiang; Liao, Kuo-Chieh; Safford, Hannah C; Thatte, Ajay S; Geisler, Hannah C; Xu, Junchao; Saw, Tzuen Yih; Wan, Yue; Mitchell, Michael J

发表日期：2025

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Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy

载药双特异性T细胞纳米衔接器克服T细胞耗竭，实现强效癌症免疫治疗

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2409564122

Wang, Jinjin; Huang, Xisha; Shi, Qiangqiang; Swingle, Kelsey L; Hamilton, Alex G; Gong, Ningqiang; Mitchell, Michael J

细胞生物学

免疫/内分泌

发表日期：2025

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Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta

探究脂质纳米颗粒弹性对胎盘mRNA递送的作用

期刊:Nano Letters

影响因子:9.1

doi:10.1021/acs.nanolett.4c06241

Safford, Hannah C; Shuler, Cecilia F; Geisler, Hannah C; Thatte, Ajay S; Swingle, Kelsey L; Han, Emily L; Murray, Amanda M; Hamilton, Alex G; Yamagata, Hannah M; Mitchell, Michael J

发表日期：2025

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Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta

用于胎盘mRNA递送的脂质纳米颗粒工程的正交实验设计

影响因子:12.1

doi:10.1002/smll.202303568

Safford, Hannah C; Swingle, Kelsey L; Geisler, Hannah C; Hamilton, Alex G; Thatte, Ajay S; Ghalsasi, Aditi A; Billingsley, Margaret M; Alameh, Mohamad-Gabriel; Weissman, Drew; Mitchell, Michael J

发表日期：2024

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EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta

靶向EGFR的可电离脂质纳米颗粒可增强体内mRNA向胎盘的递送

期刊:Journal of Controlled Release

影响因子:11.5

doi:10.1016/j.jconrel.2024.05.036

Geisler, Hannah C; Ghalsasi, Aditi A; Safford, Hannah C; Swingle, Kelsey L; Thatte, Ajay S; Mukalel, Alvin J; Gong, Ningqiang; Hamilton, Alex G; Han, Emily L; Nachod, Benjamin E; Padilla, Marshall S; Mitchell, Michael J

发表日期：2024

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In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells.

子宫内递送靶向可电离脂质纳米颗粒有助于造血干细胞的体内基因编辑

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2400783121

Palanki Rohan, Riley John S, Bose Sourav K, Luks Valerie, Dave Apeksha, Kus Nicole, White Brandon M, Ricciardi Adele S, Swingle Kelsey L, Xue Lulu, Sung Derek, Thatte Ajay S, Safford Hannah C, Chaluvadi Venkata S, Carpenter Marco, Han Emily L, Maganti Rohin, Hamilton Alex G, Mrksich Kaitlin, Billingsley Margaret B, Zoltick Philip W, Alameh Mohamad-Gabriel, Weissman Drew, Mitchell Michael J, Peranteau William H

发育与干细胞

细胞生物学

发表日期：2024

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Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy

用于妊娠期胎盘体内mRNA递送的可电离脂质纳米颗粒

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.2c12893

Swingle, Kelsey L; Safford, Hannah C; Geisler, Hannah C; Hamilton, Alex G; Thatte, Ajay S; Billingsley, Margaret M; Joseph, Ryann A; Mrksich, Kaitlin; Padilla, Marshall S; Ghalsasi, Aditi A; Alameh, Mohamad-Gabriel; Weissman, Drew; Mitchell, Michael J

发表日期：2023

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Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

生物技术：利用脂质纳米颗粒克服核酸递送的生物屏障

期刊:PLoS Biology

影响因子:7.2

doi:10.1371/journal.pbio.3002105

Hamilton, Alex G; Swingle, Kelsey L; Mitchell, Michael J

发表日期：2023

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