Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β-Hydroxylation of Lithocholic Acid
通过改造P450单加氧酶的区域选择性,可实现通过石胆酸的7β-羟基化合成熊去氧胆酸。
期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202012675
Grobe, Sascha; Badenhorst, Christoffel P S; Bayer, Thomas; Hamnevik, Emil; Wu, Shuke; Grathwol, Christoph W; Link, Andreas; Koban, Sven; Brundiek, Henrike; Großjohann, Beatrice; Bornscheuer, Uwe T