miRNA profiling reveals that gga-let-7i/COL1A2 axis induces cell cycle arrest and triggers cellular senescence to accelerate ovarian aging in laying hens by suppressing the PI3K/AKT/MDM2 pathway
miRNA谱分析表明,gga-let-7i/COL1A2轴通过抑制PI3K/AKT/MDM2通路诱导细胞周期阻滞并触发细胞衰老,从而加速产蛋鸡卵巢衰老。
期刊:Poultry Science
影响因子:4.2
doi:10.1016/j.psj.2026.106542
Wei, Yuanhang; Liao, Chimei; Wang, Yixuan; Cui, Can; Zhang, Yao; Li, Zhuanjian; Sun, Congjiao; Zhu, Qing; Yin, Huadong; Han, Shunshun
信号转导
MDM2
细胞衰老
COL1A2
miRNA
衰老
COL
细胞生物学
AKT