Psammaplysene D overcomes sorafenib resistance in liver cancer by targeting FGFR4/CYP26A1-retinoic acid axis to drive ferroptosis.
Psammaplysene D 通过靶向 FGFR4/CYP26A1-视黄酸轴来驱动铁死亡，从而克服肝癌中的索拉非尼耐药性。
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-025-03622-1
Yang Ting, Han Yanlu, Wang Yuting, Li Ruyu, Zhang Xiaonan, Zhang Xinxin, Xu Xiaohan, Xu Jing, Li Xiaoyu, Lin Chunhua, Wang Wen, Yang Jinbo
