Han Yanxiao相关文献与解析，生知库 | 链接生命科学的每一步

Tian, Yuhua; Bae, Soohyeon; Wu, Xuesong; Rouen, Kyle C; Hernández-Gonzalez, Adriana; Han, Yanxiao; Tekreeti, Abdullah Al; Vu, Simon; Chen, Irene; Li, Ellen; Vorobyov, Igor; Yarov-Yarovoy, Vladimir; Suh, Byung-Chang; Hwang, Samuel T; Zheng, Jie

TRPM4

发表日期：2026

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DKC1: a robust prognostic factor and potential therapeutic target in multiple myeloma.

DKC1：多发性骨髓瘤的可靠预后因素和潜在治疗靶点。

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-026-07916-6

Sun Chenxi, Cheng Lin, Li Ai, Han Yanxiao, Wang Yongjing, Xiao Juan, Guo Yanan, Zhang Wenting, Sun Likun, Xu Dawei, Kong Dexiao, Jiang Yang, Zheng Chengyun

AMP-36 exhibits potent therapeutic efficacy against MRSA pneumonia through membrane-target mechanism

AMP-36 通过膜靶向机制对耐甲氧西林金黄色葡萄球菌肺炎表现出强大的治疗功效。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-44156-6

Han, Yanxiao; Wang, Yuli; Cheng, Lin; Sun, Chenxi; Song, Jialin; Zhang, Xunqi; Zhang, Xuhua; Jiang, Yang; Li, Xiaoyan; Kong, Dexiao; Zheng, Chengyun

肺炎

发表日期：2026

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Correction: Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3

更正：间充质干细胞中白细胞介素-1受体拮抗剂的过表达通过HtrA丝氨酸肽酶3改善出血性膀胱炎的预后

期刊:Stem Cell Research & Therapy

影响因子:7.3

doi:10.1186/s13287-025-04494-0

Song, Jialin; Han, Yanxiao; Chen, Yuyan; Cheng, Lin; Xiao, Juan; Li, Ai; Kong, Dexiao; Jiang, Yang; Zheng, Chengyun

Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3.

间充质干细胞中白细胞介素-1受体拮抗剂的过度表达通过HtrA丝氨酸肽酶3改善出血性膀胱炎的预后

期刊:Stem Cell Research & Therapy

影响因子:7.3

doi:10.1186/s13287-025-04443-x

Song Jialin, Han Yanxiao, Chen Yuyan, Cheng Lin, Xiao Juan, Li Ai, Kong Dexiao, Jiang Yang, Zheng Chengyun

Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein

分子模拟揭示了激动剂结合的β-肾上腺素能受体与G蛋白之间复杂的耦合关系。

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2024.111741

Han, Yanxiao; Dawson, John R D; DeMarco, Kevin R; Rouen, Kyle C; Ngo, Khoa; Bekker, Slava; Yarov-Yarovoy, Vladimir; Clancy, Colleen E; Xiang, Yang K; Ahn, Surl-Hee; Vorobyov, Igor

Prediction of TdP Arrhythmia Risk Through Molecular Simulations of Conformation-specific Drug Interactions with the hERG K(+), Na(v)1.5, and Ca(v)1.2 Channels

通过分子模拟药物与 hERG K(+)、Na(v)1.5 和 Ca(v)1.2 通道的构象特异性相互作用来预测尖端扭转型室性心动过速 (TdP) 心律失常风险

期刊:

影响因子:

doi:10.1101/2025.09.25.678690

Rouen, Kyle C; Narang, Kush; Han, Yanxiao; Wang, David; Jang, Ensley; Brunkow, Sophia; Yarov-Yarovoy, Vladimir; MacKerell, Alexander D Jr; Vorobyov, Igor

ERG

发表日期：2025

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Atomistic mechanisms of the regulation of small-conductance Ca(2+)-activated K(+) channel (SK2) by PIP2

PIP2 调控小电导 Ca(2+) 激活 K(+) 通道 (SK2) 的原子机制

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2318900121

Woltz, Ryan L; Zheng, Yang; Choi, Woori; Ngo, Khoa; Trinh, Pauline; Ren, Lu; Thai, Phung N; Harris, Brandon J; Han, Yanxiao; Rouen, Kyle C; Mateos, Diego Lopez; Jian, Zhong; Chen-Izu, Ye; Dickson, Eamonn J; Yamoah, Ebenezer N; Yarov-Yarovoy, Vladimir; Vorobyov, Igor; Zhang, Xiao-Dong; Chiamvimonvat, Nipavan

信号转导

发表日期：2024

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Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

阐明原毒素 II 与人 NaV1.7 通道状态特异性结合的分子机制

期刊:Journal of General Physiology

影响因子:2.9

doi:10.1085/jgp.202313368

Ngo, Khoa; Lopez Mateos, Diego; Han, Yanxiao; Rouen, Kyle C; Ahn, Surl-Hee; Wulff, Heike; Clancy, Colleen E; Yarov-Yarovoy, Vladimir; Vorobyov, Igor

发表日期：2024

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Dendrimer-Peptide Conjugates for Effective Blockade of the Interactions between SARS-CoV-2 Spike Protein and Human ACE2 Receptor

树状聚合物-肽缀合物可有效阻断SARS-CoV-2刺突蛋白与人ACE2受体之间的相互作用

期刊:Biomacromolecules

影响因子:5.4

doi:10.1021/acs.biomac.2c01018

Jeong, Woo-Jin; Bu, Jiyoon; Mickel, Philip; Han, Yanxiao; Rawding, Piper A; Wang, Jianxin; Kang, Hanbit; Hong, Heejoo; Král, Petr; Hong, Seungpyo

Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases

热依赖性和 PIP2 依赖性的 TRPM4 活性是两种互斥的人类疾病的基础。

DKC1: a robust prognostic factor and potential therapeutic target in multiple myeloma.

DKC1：多发性骨髓瘤的可靠预后因素和潜在治疗靶点。

AMP-36 exhibits potent therapeutic efficacy against MRSA pneumonia through membrane-target mechanism

AMP-36 通过膜靶向机制对耐甲氧西林金黄色葡萄球菌肺炎表现出强大的治疗功效。

Correction: Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3

更正：间充质干细胞中白细胞介素-1受体拮抗剂的过表达通过HtrA丝氨酸肽酶3改善出血性膀胱炎的预后

Interleukin-1 receptor antagonist overexpression in mesenchymal stem cells improves hemorrhagic cystitis outcomes via HtrA serine peptidase 3.

间充质干细胞中白细胞介素-1受体拮抗剂的过度表达通过HtrA丝氨酸肽酶3改善出血性膀胱炎的预后

Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein

分子模拟揭示了激动剂结合的β-肾上腺素能受体与G蛋白之间复杂的耦合关系。

Prediction of TdP Arrhythmia Risk Through Molecular Simulations of Conformation-specific Drug Interactions with the hERG K(+), Na(v)1.5, and Ca(v)1.2 Channels

通过分子模拟药物与 hERG K(+)、Na(v)1.5 和 Ca(v)1.2 通道的构象特异性相互作用来预测尖端扭转型室性心动过速 (TdP) 心律失常风险

Atomistic mechanisms of the regulation of small-conductance Ca(2+)-activated K(+) channel (SK2) by PIP2

PIP2 调控小电导 Ca(2+) 激活 K(+) 通道 (SK2) 的原子机制

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

阐明原毒素 II 与人 NaV1.7 通道状态特异性结合的分子机制

Dendrimer-Peptide Conjugates for Effective Blockade of the Interactions between SARS-CoV-2 Spike Protein and Human ACE2 Receptor

树状聚合物-肽缀合物可有效阻断SARS-CoV-2刺突蛋白与人ACE2受体之间的相互作用