日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids.

MTMR通过控制质膜磷脂水平来调节KRAS功能

Lange Taylor E, Naji Ali, van der Hoeven Ransome, Liang Hong, Zhou Yong, Hammond Gerald R V, Hancock John F, Cho Kwang-Jin

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors

DIRAS3衍生的环状肽破坏KRAS-RAF相互作用和KRAS纳米簇集,从而抑制KRAS驱动的胰腺癌和卵巢癌。

Gray, Joshua P; Bildik, Gamze; Kim, Ha-Neul; Sutton, Margie N; Wang, Jing; Osuji, Amarachi O; Batistatou, Nefeli; Yang, Hailing; Mao, Weiqun; Tan, Zhi; Gasmi-Seabrook, Geneviève M C; Liu, Junchen; Hancock, John F; Marshall, Christopher B; Kritzer, Joshua A; Ikura, Mitsuhiko; Bast, Robert C Jr; Millward, Steven W; Lu, Zhen

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

关于RAS二聚化假说的共识:有强有力的证据表明脂质介导的聚集,但缺乏G结构域介导的相互作用的证据。

Simanshu, Dhirendra K; Philips, Mark R; Hancock, John F

Direct Modulators of K-Ras-Membrane Interactions

K-Ras-膜相互作用的直接调节因子

Morstein, Johannes; Shrestha, Rebika; Van, Que N; López, César A; Arora, Neha; Tonelli, Marco; Liang, Hong; Chen, De; Zhou, Yong; Hancock, John F; Stephen, Andrew G; Turbyville, Thomas J; Shokat, Kevan M

RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling

RAS纳米簇是细胞表面传感器,可将细胞外刺激转化为细胞内信号。

Zhou, Yong; Hancock, John F

The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure

KRAS和其他异戊二烯化多碱性结构域膜锚蛋白识别磷脂酰丝氨酸酰基链结构

Zhou, Yong; Prakash, Priyanka S; Liang, Hong; Gorfe, Alemayehu A; Hancock, John F

Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer

磷脂酰丝氨酸内质网至质膜转运机制的组成部分作为胰腺癌中KRAS抑制的靶点

Kattan, Walaa E; Liu, Junchen; Montufar-Solis, Dina; Liang, Hong; Brahmendra Barathi, Bhargavi; van der Hoeven, Ransome; Zhou, Yong; Hancock, John F

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

Caveolin-1 和 cavin1 协同作用,在 Caveolae 中产生独特的脂质环境。

Zhou, Yong; Ariotti, Nicholas; Rae, James; Liang, Hong; Tillu, Vikas; Tee, Shern; Bastiani, Michele; Bademosi, Adekunle T; Collins, Brett M; Meunier, Frederic A; Hancock, John F; Parton, Robert G

Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors

芬地林支架的重新利用:鉴定强效的KRAS质膜定位抑制剂

Wang, Pingyuan; van der Hoeven, Dharini; Ye, Na; Chen, Haiying; Liu, Zhiqing; Ma, Xiaoping; Montufar-Solis, Dina; Rehl, Kristen M; Cho, Kwang-Jin; Thapa, Sabita; Chen, Wei; van der Hoeven, Ransome; Frost, Jeffrey A; Hancock, John F; Zhou, Jia

Osimertinib-resistant NSCLC cells activate ERBB2 and YAP/TAZ and are killed by neratinib.

奥希替尼耐药的非小细胞肺癌细胞激活ERBB2和YAP/TAZ,并被奈拉替尼杀死

Dent Paul, Booth Laurence, Poklepovic Andrew, Von Hoff Daniel, Martinez Jennifer, Zhou Yong, Hancock John F