High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.
对 C9ORF72 ALS 神经元中的 100,000 个小分子进行高通量筛选，鉴定出剪接体调节剂，这些调节剂可使 G4C2 重复 RNA 动员到核输出和重复相关的非经典翻译
期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf253
Luteijn Maartje J, Bhaskar Varun, Trojer Dominic, Schürz Melanie, Mahboubi Hicham, Handl Cornelia, Pizzato Nicolas, Pfeifer Martin, Dafinca Ruxandra, Voshol Hans, Giorgetti Elisa, Manneville Carole, Garnier Isabelle P M, Müller Matthias, Zeng Fanning, Buntin Kathrin, Markwalder Roger, Schröder Harald, Weiler Jan, Khar Dora, Schuhmann Tim, Groot-Kormelink Paul J, Keller Caroline Gubser, Farmer Pierre, MacKay Angela, Beibel Martin, Roma Guglielmo, D'Ario Giovanni, Merkl Claudia, Schebesta Michael, Hild Marc, Elwood Fiona, Vahsen Björn F, Ripin Nina, Clery Antoine, Allain Frederic, Labow Mark, Gabriel Daniela, Chao Jeffrey A, Talbot Kevin, Nash Mark, Hunziker Jürg, Meisner-Kober Nicole C
