Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung.
GS-441524 前药在细胞和小鼠模型中的差异生物活化特征：具有高细胞渗透性和对组织蛋白酶 A 敏感性的 ProTide 前药能更有效地将抗病毒活性代谢物输送到肺部
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c00234
Li Jiapeng, de Melo Jorge Daniel Macedo, Wang Weiwen, Sun Shuxin, Frum Tristan, Hang Yu-An, Liu Yueting, Zhou Xingwu, Xiao Jingcheng, Wang Xinwen, Spence Jason R, Wobus Christiane E, Zhu Hao-Jie
