Disruption of the Clock Component BMAL1 in HDM-induced Asthma Causes GC Resistance in Airway Epithelial Cells by Regulating GR Phosphorylation through the DUSP4-p38MAPK Pathway.
尘螨诱发的哮喘中时钟成分 BMAL1 的破坏通过 DUSP4-p38MAPK 通路调节 GR 磷酸化,导致气道上皮细胞产生糖皮质激素抵抗。
期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.119486
Huang Haohua, Liao Hua, Chen Yixin, Hu Minxuan, Jiang Xiaoxiao, Yu Qi, Gao Yimei, Yang Huimin, Zhuo Jinzhong, Liu Dongyu, Huang Liping, Zhang Jinming, Li Yanqun, Du Yuhan, Lin Xiaodong, Meng Xiaojing, Zou Fei, Zou Mengchen, Wu Jieyu, Cai Shaoxi, Dong Hangming
哮喘
上皮细胞
信号转导
MAPK/ERK
BMAL1
磷酸化
细胞生物学
SP4
免疫/内分泌