Hanl相关文献与解析，生知库 | 链接生命科学的每一步

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties.

探索组蛋白去乙酰化酶 (HDAC) 抑制剂中的替代锌结合基团，发现 DS-103 是一种具有化学增敏特性的强效乙基肼基 HDAC 抑制剂

doi:10.1021/acs.jmedchem.4c02373

Stopper Daniel, Biermann Lukas, Watson Paris R, Li Jingyu, KÃ¶nig Beate, Gaynes Matthew N, Pessanha de Carvalho Lais, Klose Jana, Hanl Maria, Hamacher Alexandra, SchÃ¤ker-HÃ¼bner Linda, Ramsbeck Daniel, Held Jana, Christianson David W, Kassack Matthias U, Hansen Finn K

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders.

首个选择性 IIb 类组蛋白去乙酰化酶降解剂的开发和表征

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c00674

Zhai Shiyang, Honin Irina, SchÃ¤ker-HÃ¼bner Linda, Hanl Maria, Jacobi Lukas, Dressler Finn, PieÅkowska Dominika Ewa, KÃ¶nig Philipp, Gerhartz Jan, Voget Rabea, Bendas Gerd, GÃ¼tschow Michael, Meissner Felix, Burckhardt Bjoern B, Nowak RadosÅaw P, Steinebach Christian, Hansen Finn K

Target Engagement Studies and Kinetic Live-Cell Degradation Assays Enable the Systematic Characterization of Histone Deacetylase 6 Degraders

靶标结合研究和动力学活细胞降解分析能够系统地表征组蛋白去乙酰化酶 6 降解剂

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.5c00247

Hanl, Maria; Feller, Felix; Honin, Irina; Tan, Kathrin; Miranda, Martina; Schäker-Hübner, Linda; Bückreiß, Nico; Schiedel, Matthias; Gütschow, Michael; Bendas, Gerd; Hansen, Finn K

Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6

光激活光化学靶向嵌合体（PHOTACs）能够实现对HDAC6靶向蛋白降解的光学控制。

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d4md00972j

Wurnig, Silas L; Hanl, Maria; Geiger, Thomas M; Zhai, Shiyang; Dressel, Ina; Pieńkowska, Dominika E; Nowak, Radosław P; Hansen, Finn K

Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader

用 DDB1 和 CUL4 相关因子 11 (DCAF11) 募集因子取代 Cereblon 配体，可将选择性组蛋白去乙酰化酶 6 PROTAC 转化为泛降解酶。

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202500035

Feller, Felix; Weber, Heiko; Miranda, Martina; Honin, Irina; Hanl, Maria; Hansen, Finn K

Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors

固相平行合成双重组蛋白去乙酰化酶-环氧合酶抑制剂

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules28031061

Luisa M Bachmann ，Maria Hanl ，Felix Feller ，Laura Sinatra ，Andrea Schöler ，Jens Pietzsch ，Markus Laube ，Finn K Hansen

Task-specific auditory distraction in serial recall and mental arithmetic

任务特定听觉干扰对序列回忆和心算的影响

期刊:Memory & Cognition

影响因子:2.1

doi:10.3758/s13421-022-01363-6

Kattner, Florian; Hanl, Sarah; Paul, Linda; Ellermeier, Wolfgang

发表日期：2023

文献求助收藏

Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy

光笼组蛋白去乙酰化酶抑制剂作为癌症靶向治疗的前体药物

期刊:Pharmaceuticals

影响因子:

doi:10.3390/ph16030356

Fabian B Kraft, Maria Hanl, Felix Feller, Linda Schäker-Hübner, Finn K Hansen

Remediating Garden Soils: EDTA-Soil Washing and Safe Vegetable Production in Raised Bed Gardens

改良花园土壤：EDTA土壤清洗法和高架菜园安全蔬菜生产

期刊:Toxics

影响因子:4.1

doi:10.3390/toxics10110652

Noller, Christoph; Friesl-Hanl, Wolfgang; Hood-Nowotny, Rebecca; Watzinger, Andrea

发表日期：2022

文献求助收藏

Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders

首创的FEM1B募集组蛋白去乙酰化酶降解剂的开发

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties.

探索组蛋白去乙酰化酶 (HDAC) 抑制剂中的替代锌结合基团，发现 DS-103 是一种具有化学增敏特性的强效乙基肼基 HDAC 抑制剂

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders.

首个选择性 IIb 类组蛋白去乙酰化酶降解剂的开发和表征

Target Engagement Studies and Kinetic Live-Cell Degradation Assays Enable the Systematic Characterization of Histone Deacetylase 6 Degraders

靶标结合研究和动力学活细胞降解分析能够系统地表征组蛋白去乙酰化酶 6 降解剂

Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6

光激活光化学靶向嵌合体（PHOTACs）能够实现对HDAC6靶向蛋白降解的光学控制。

Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader

用 DDB1 和 CUL4 相关因子 11 (DCAF11) 募集因子取代 Cereblon 配体，可将选择性组蛋白去乙酰化酶 6 PROTAC 转化为泛降解酶。

Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors

固相平行合成双重组蛋白去乙酰化酶-环氧合酶抑制剂

Task-specific auditory distraction in serial recall and mental arithmetic

任务特定听觉干扰对序列回忆和心算的影响

Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy

光笼组蛋白去乙酰化酶抑制剂作为癌症靶向治疗的前体药物

Remediating Garden Soils: EDTA-Soil Washing and Safe Vegetable Production in Raised Bed Gardens

改良花园土壤：EDTA土壤清洗法和高架菜园安全蔬菜生产