日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response.

对免疫热肿瘤和免疫冷肿瘤进行单细胞和空间分析,可以识别与不同免疫微环境和积极免疫治疗反应相关的成纤维细胞亚型

Jenkins Benjamin H, Tracy Ian, Rodrigues Maria Fernanda S D, Smith Melanie J L, Martinez Begoña R, Edmond Mark, Mahadevan Sangeetha, Rao Anjali, Zong Hailing, Liu Kai, Aggarwal Abhishek, Li Li, Diehl Lauri, King Emma V, Bates Jamie G, Hanley Christopher J, Thomas Gareth J

Targeting cancer associated fibroblasts to enhance immunotherapy: emerging strategies and future perspectives

靶向癌症相关成纤维细胞以增强免疫疗法:新兴策略和未来展望

Hanley, Christopher J; Thomas, Gareth J

T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting

T细胞肿瘤排斥和免疫治疗耐药:CAF靶向治疗的作用

Hanley, Christopher J; Thomas, Gareth J

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

通过抑制NOX4靶向肌成纤维细胞癌相关成纤维细胞表型

Hanley, Christopher J; Mellone, Massimiliano; Ford, Kirsty; Thirdborough, Steve M; Mellows, Toby; Frampton, Steven J; Smith, David M; Harden, Elena; Szyndralewiez, Cedric; Bullock, Marc; Noble, Fergus; Moutasim, Karwan A; King, Emma V; Vijayanand, Pandurangan; Mirnezami, Alex H; Underwood, Timothy J; Ottensmeier, Christian H; Thomas, Gareth J

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

胰腺癌中αvβ6整合素的促迁移和TGF-β激活功能通过Eps8依赖的GTP酶开关进行差异性调节

Tod Jo, Hanley Christopher J, Morgan Mark R, Rucka Marta, Mellows Toby, Lopez Maria-Antoinette, Kiely Philip, Moutasim Karwan A, Frampton Steven J, Sabnis Durgagauri, Fine David R, Johnson Colin, Marshall John F, Scita Giorgio, Jenei Veronika, Thomas Gareth J

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

mTOR通过调节MAPKAPK2的翻译来控制衰老相关分泌表型

Herranz, Nicolás; Gallage, Suchira; Mellone, Massimiliano; Wuestefeld, Torsten; Klotz, Sabrina; Hanley, Christopher J; Raguz, Selina; Acosta, Juan Carlos; Innes, Andrew J; Banito, Ana; Georgilis, Athena; Montoya, Alex; Wolter, Katharina; Dharmalingam, Gopuraja; Faull, Peter; Carroll, Thomas; Martínez-Barbera, Juan Pedro; Cutillas, Pedro; Reisinger, Florian; Heikenwalder, Mathias; Miller, Richard A; Withers, Dominic; Zender, Lars; Thomas, Gareth J; Gil, Jesús