日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss

携带 TREM2 R47H/+ 突变的 iPSC 衍生小胶质细胞具有促炎作用并促进突触丢失

Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsai

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation

一种将 HDAC/MECP2 复合物募集到 PU.1 基序的新型分子类可减少神经炎症

William T Ralvenius, Alison E Mungenast, Hannah Woolf, Margaret M Huston, Tyler Z Gillingham, Stephen K Godin, Jay Penney, Hugh P Cam, Fan Gao, Celia G Fernandez, Barbara Czako, Yaima Lightfoot, William J Ray, Adrian Beckmann, Alison M Goate, Edoardo Marcora, Carmen Romero-Molina, Pinar Ayata, Anne